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Foghorn Therapeutics (FHTX) investor relations material
Foghorn Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025
Company overview and strategic focus
Focused on precision oncology, particularly chromatin regulation, with up to 50% of cancers linked to this biology.
Pipeline includes classical enzymatic inhibitors and newer protein degradation approaches.
Multiple programs in development, with a key partnership for the 909 study targeting SMARCA2.
909 program and clinical development
909 is an enzymatic inhibitor targeting SMARCA2, synthetic lethal with SMARCA4 mutations, mainly in non-small cell lung cancer.
Decision on expansion with Lilly expected in the first half of next year; top-line efficacy and safety data to be disclosed if material.
Dose expansion aims to move quickly into first-line metastatic non-small cell lung cancer, combining with pembrolizumab and chemotherapy.
Enrollment is strong, with 15 US sites, 5 in Japan, and new sites opening in Europe and South Korea.
Backfilling cohorts now underway, focusing on patients with true loss-of-function SMARCA4 mutations.
Clinical insights and competitive landscape
High target coverage (IC90/DC90) is critical for efficacy; prior competitor programs failed due to inadequate coverage.
Dose-response is clear: higher inhibition/degradation leads to tumor regression, not just growth inhibition.
Fourth-line non-small cell lung cancer patients have poor prognosis; meaningful efficacy would be responses >15% and duration >4 months.
Efficacy is expected to be higher in Class 1 (true loss-of-function) SMARCA4 mutations.
Safety profile so far is manageable; no maximum tolerated dose reached, but prior programs saw tolerability issues at higher doses.
What 909 efficacy bar is needed for expansion?
What did Prelude's SMARC-II failure clarify?
What differentiates your selective EP300 program?
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Next Foghorn Therapeutics earnings date
Q4 20256 Mar, 2026
Next Foghorn Therapeutics earnings date
Q4 20256 Mar, 2026
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Frequently asked questions
Foghorn Therapeutics Inc. is a clinical-stage biopharmaceutical company specializing in the discovery and development of novel therapies targeting the chromatin regulatory system, which plays a critical role in gene expression and cellular identity. The company leverages its proprietary Gene Traffic Control platform to gain an integrated understanding of how chromatin regulation affects disease, enabling it to identify and develop potential drug candidates. Foghorn's research focuses on treating genetically determined dependencies in various cancers, including hematologic malignancies and solid tumors. The company has collaborations with major pharmaceutical firms to further its therapeutic pipeline. Foghorn Therapeutics is headquartered in Cambridge, Massachusetts, and its shares are listed on the NASDAQ.
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