Foghorn Therapeutics
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Foghorn Therapeutics (FHTX) investor relations material

Foghorn Therapeutics TD Cowen 46th Annual Health Care Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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TD Cowen 46th Annual Health Care Conference summary3 Mar, 2026

Strategic partnerships and pipeline overview

  • Partnership with Eli Lilly includes a 50/50 collaboration on the SMARCA2 program, with additional targets under Lilly's rights and a significant oncology deal established in December 2021.

  • Proprietary pipeline features selective CBP, EP300, and ARID1B degrader programs, with IND-enabling studies for CBP and EP300 expected later this year and in vivo proof of concept for ARID1B targeted for 2026.

  • An I&I program with a novel target is projected for IND in 2027, pending continued validation.

  • The company is advancing induced proximity approaches, with more developments anticipated over the next year.

  • Recent $50 million direct offering extends financial runway by approximately two quarters at current burn rate.

Clinical progress and trial updates

  • SMARCA2 program is in dose escalation, with no maximum tolerated dose reached; sites are open in the US, Japan, France, Germany, Spain, and South Korea.

  • Backfilling of cohorts began in Q4, focusing on non-small cell lung cancer patients with strong loss-of-function SMARCA4 mutations.

  • Decision on dose expansion is expected around mid-year, depending on ongoing phase 1 results.

  • Enrollment has been efficient due to proactive site openings, facilitating seamless transition to expansion if warranted.

  • Safety and tolerability have been favorable, with no dose-limiting toxicities reported to date.

Scientific and clinical rationale

  • Chromatin regulatory system mutations are prevalent in oncology and other diseases, with selective drugging achieved after years of effort.

  • SMARCA4-mutant non-small cell lung cancer patients have poor prognosis, especially when co-mutated with KRAS, highlighting high unmet need.

  • Combination strategies with KRAS inhibitors are anticipated in future expansion phases.

  • CBP and EP300 degraders show promising preclinical efficacy and improved safety profiles compared to dual bromodomain inhibitors.

  • ARID1B degrader program is progressing, with selective degradation achieved and in vivo proof of concept targeted for 2026.

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Q4 202513 Mar, 2026
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Frequently asked questions

Foghorn Therapeutics Inc. is a clinical-stage biopharmaceutical company specializing in the discovery and development of novel therapies targeting the chromatin regulatory system, which plays a critical role in gene expression and cellular identity. The company leverages its proprietary Gene Traffic Control platform to gain an integrated understanding of how chromatin regulation affects disease, enabling it to identify and develop potential drug candidates. Foghorn's research focuses on treating genetically determined dependencies in various cancers, including hematologic malignancies and solid tumors. The company has collaborations with major pharmaceutical firms to further its therapeutic pipeline. Foghorn Therapeutics is headquartered in Cambridge, Massachusetts, and its shares are listed on the NASDAQ.

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