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Foghorn Therapeutics (FHTX) investor relations material
Foghorn Therapeutics TD Cowen 46th Annual Health Care Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Strategic partnerships and pipeline overview
Partnership with Eli Lilly includes a 50/50 collaboration on the SMARCA2 program, with additional targets under Lilly's rights and a significant oncology deal established in December 2021.
Proprietary pipeline features selective CBP, EP300, and ARID1B degrader programs, with IND-enabling studies for CBP and EP300 expected later this year and in vivo proof of concept for ARID1B targeted for 2026.
An I&I program with a novel target is projected for IND in 2027, pending continued validation.
The company is advancing induced proximity approaches, with more developments anticipated over the next year.
Recent $50 million direct offering extends financial runway by approximately two quarters at current burn rate.
Clinical progress and trial updates
SMARCA2 program is in dose escalation, with no maximum tolerated dose reached; sites are open in the US, Japan, France, Germany, Spain, and South Korea.
Backfilling of cohorts began in Q4, focusing on non-small cell lung cancer patients with strong loss-of-function SMARCA4 mutations.
Decision on dose expansion is expected around mid-year, depending on ongoing phase 1 results.
Enrollment has been efficient due to proactive site openings, facilitating seamless transition to expansion if warranted.
Safety and tolerability have been favorable, with no dose-limiting toxicities reported to date.
Scientific and clinical rationale
Chromatin regulatory system mutations are prevalent in oncology and other diseases, with selective drugging achieved after years of effort.
SMARCA4-mutant non-small cell lung cancer patients have poor prognosis, especially when co-mutated with KRAS, highlighting high unmet need.
Combination strategies with KRAS inhibitors are anticipated in future expansion phases.
CBP and EP300 degraders show promising preclinical efficacy and improved safety profiles compared to dual bromodomain inhibitors.
ARID1B degrader program is progressing, with selective degradation achieved and in vivo proof of concept targeted for 2026.
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