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Generation Bio (GBIO) investor relations material

Generation Bio Q2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q2 2025 earnings summary12 Aug, 2025

Executive summary

  • Announced a strategic restructuring with a 90% workforce reduction and exploration of strategic alternatives, including potential sale or merger, to maximize shareholder value, with TD Cowen as financial advisor.

  • Initiated a strategic review process and began phased restructuring, including R&D staff.

  • Announced new data showing selective delivery of siRNA to T cells in non-human primates using ctLNP, with potent knockdown of LAT1 and VAV1.

  • Regained Nasdaq compliance following a 1-for-10 reverse stock split effective July 21, 2025.

  • Entered a $31.0 million settlement in August 2025 to resolve Seyon Lease litigation, with mutual releases and dismissal of litigation.

Financial highlights

  • Cash, cash equivalents, and marketable securities totaled $141.4 million as of June 30, 2025, down from $185.2 million at year-end 2024.

  • Net loss was $20.9 million for Q2 2025 and $35.7 million for the first half of 2025, compared to $20.4 million and $95.0 million, respectively, in 2024.

  • R&D expenses were $15.5 million and G&A expenses were $7.7 million for Q2 2025, both down from Q2 2024.

  • Working capital was $126.1 million and total assets $179.4 million as of June 30, 2025.

  • Total stockholders' equity was $54.1 million as of June 30, 2025.

Outlook and guidance

  • Restructuring costs of $12.0–$15.0 million expected, mainly for severance and retention, to be incurred in Q3 and Q4 2025.

  • Cash runway expected to fund operations and capital expenditures for at least 12 months from the reporting date.

  • Post-litigation settlement and restructuring, cash and equivalents projected at $100 million.

  • Actual restructuring costs and savings may differ materially from estimates due to various assumptions.

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Frequently asked questions

Generation Bio Co. is a biotechnology company focused on the development of genetic medicines to treat both rare and prevalent diseases. Leveraging its proprietary platform, the company is working on a range of therapies aimed at addressing conditions affecting the liver, retina, skeletal muscle, central nervous system, and oncology. The company is headquartered in Cambridge, Massachusetts, and its shares are listed on the Nasdaq.

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