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GH Research (GHRS) investor relations material
GH Research Registration filing summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Company overview and business model
Clinical-stage biopharmaceutical company focused on developing novel mebufotenin therapies for treatment-resistant depression (TRD), with lead candidates GH001 (inhalable) and GH002 (intravenous).
GH001 has completed multiple Phase 1 and Phase 2 trials, showing potential for ultra-rapid remission in TRD patients.
Developing a proprietary aerosol delivery device for GH001, currently under clinical investigation in Europe.
Incorporated in Ireland, operates as a holding company for GH Research Ireland Limited.
Financial performance and metrics
As of March 31, 2026, 62,052,506 ordinary shares were outstanding; as of May 12, 2026, 68,608,919 shares were outstanding.
Share capital changes since January 1, 2023, include significant underwritten offerings and option exercises.
Use of proceeds and capital allocation
Net proceeds from offerings intended for research, clinical and technical development, pre-commercialization activities, working capital, capital expenditures, and general corporate purposes.
Management retains significant discretion over allocation of proceeds.
- GH001 achieved rapid, durable remission in TRD with minimal visits and strong safety.GHRS
Corporate presentation5 Mar 2026 - GH001 showed robust Phase 2b results in TRD; cash rose to $280.7M, net loss at $48.3M.GHRS
Q4 20255 Mar 2026 - GH001 delivers rapid, durable remission in TRD with strong safety and fewer clinic visits.GHRS
Status Update9 Jan 2026 - Up to $400M in securities registered to fund novel depression therapies and corporate growth.GHRS
Registration Filing16 Dec 2025 - GH001 achieved significant efficacy in TRD; cash reserves rose to $293.9M; Q3 net loss $14M.GHRS
Q3 202520 Nov 2025 - Pivotal depression program on track for 2026, with strong cash and robust Phase 2b results.GHRS
Q2 202512 Sep 2025 - Phase 2b GH001 trial enrollment completed; net loss rises as R&D spending increases.GHRS
Q3 202413 Jun 2025 - Q2 net loss widened to $10.4M as GH001 clinical programs advanced and cash runway extends into 2026.GHRS
Q2 202413 Jun 2025 - Q1 2025 saw strong GH001 trial results, robust cash, and progress on regulatory milestones.GHRS
Q1 20259 Jun 2025
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