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GH Research
GH Research (GHRS) investor relations material
GH Research Corporate presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate presentation summary5 Mar, 2026
Pipeline and financial position
Lead candidate GH001 (mebufotenin for inhalation) targets treatment-resistant depression (TRD), postpartum depression, and bipolar II disorder, with Phase 2b completed and Phase 3 initiation planned for 2026.
GH002 (mebufotenin for i.v. administration) is in early-stage trials for psychiatric disorders.
Cash, cash equivalents, and marketable securities totaled $280.7 million as of December 31, 2025.
Clinical trial design and efficacy results
Phase 2b trial in TRD used a randomized, double-blind, placebo-controlled design with an open-label extension (OLE).
GH001 achieved a placebo-adjusted mean MADRS reduction of -15.5 at Day 8 (p<0.0001), with a large effect size (Cohen's d = -2.0).
Remission rates were 57.5% at Day 8 and 73% at 6 months among OLE completers.
Initial remitters had a 90% remission rate at 6 months; 43.5% of initial non-remitters achieved remission by 6 months.
MADRS reduction was reproducible in both double-blind and OLE phases.
Comparative advantages and patient burden
GH001 showed greater efficacy and faster onset compared to Spravato and other psychedelic therapies, with a median psychoactive experience of 11 minutes.
83% fewer treatment visits required over 6 months compared to Spravato (4 vs. 23 visits).
No additional psychotherapy or therapist visits required.
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Next GH Research earnings date
Q1 20261 May, 2026
GH Research
Next GH Research earnings date
Q1 20261 May, 2026
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Frequently asked questions
GH Research PLC is a clinical-stage biopharmaceutical company focused on developing innovative therapies for psychiatric and neurological disorders. The company's primary area of research is centered on 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT), a psychoactive compound, which is being developed for treating treatment-resistant depression (TRD) and other mental health conditions. GH Research's leading product candidate, GH001, is an inhalable form of mebufotenin, currently in Phase 2b clinical trials for TRD, as well as in earlier trials for Bipolar II disorder and postpartum depression. Additionally, the company is developing GH002, an intravenous formulation, and GH003, an intranasal product. The company is headquartered in Dublin, Ireland, and its shares are listed on the NASDAQ.
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