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GH Research (GHRS) investor relations material
GH Research Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary6 Aug, 2025
Executive summary
Global pivotal program for lead depression treatment on track to begin in 2026, with regulatory engagement ongoing.
Phase 2b trial of lead candidate in treatment-resistant depression met primary endpoint, showing significant efficacy and strong safety profile at 6 months.
Cash position strengthened by Q1 2025 public offering, supporting ongoing R&D and pivotal program planning.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $308.7 million as of June 30, 2025, up from $182.6 million at year-end 2024.
Net loss for Q2 2025 was $9.3 million ($0.15 per share), compared to $10.4 million ($0.20 per share) in Q2 2024.
R&D expenses decreased to $9.0 million from $9.8 million year-over-year, while G&A expenses rose to $5.7 million from $3.5 million.
Finance income increased to $3.1 million in Q2 2025 from $2.6 million in Q2 2024.
Outlook and guidance
Global pivotal program initiation expected in 2026, with ongoing regulatory input and end-of-Phase 2 meeting preparation.
IND submission for intravenous product candidate GH002 planned for Q4 2025.
Describe the remaining GH001 IND hold topic?
How will Phase 2b data shape pivotal program design?
What is the strategic role of GH002 vs GH001?
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Next GH Research earnings date
Q3 20257 Nov, 2025
Next GH Research earnings date
Q3 20257 Nov, 2025
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Frequently asked questions
GH Research PLC is a clinical-stage biopharmaceutical company focused on developing innovative therapies for psychiatric and neurological disorders. The company's primary area of research is centered on 5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT), a psychoactive compound, which is being developed for treating treatment-resistant depression (TRD) and other mental health conditions. GH Research's leading product candidate, GH001, is an inhalable form of mebufotenin, currently in Phase 2b clinical trials for TRD, as well as in earlier trials for Bipolar II disorder and postpartum depression. Additionally, the company is developing GH002, an intravenous formulation, and GH003, an intranasal product. The company is headquartered in Dublin, Ireland, and its shares are listed on the NASDAQ.
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