GRI Bio
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GRI Bio (GRI) investor relations material

GRI Bio Q4 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q4 2025 earnings summary30 Jan, 2026

Executive summary

  • Clinical-stage biopharma focused on therapies for inflammatory, fibrotic, and autoimmune diseases, with lead candidate GRI-0621 targeting idiopathic pulmonary fibrosis (IPF).

  • GRI-0621 met primary and secondary endpoints in a Phase 2a IPF trial, showing safety, tolerability, and biomarker improvements.

  • GRI-0803, targeting lupus and other autoimmune disorders, is advancing toward IND-enabling studies and a Phase 1 trial in 2026.

  • Company remains pre-revenue, with ongoing net losses and a focus on advancing clinical programs and securing additional capital.

Financial highlights

  • Net loss for 2025 was $12.0 million, compared to $8.2 million in 2024.

  • Research and development expenses increased to $6.8 million in 2025 from $3.8 million in 2024, mainly due to GRI-0621 clinical development.

  • General and administrative expenses rose to $5.2 million in 2025 from $4.5 million in 2024.

  • Cash and cash equivalents as of December 31, 2025, were $8.2 million.

  • Accumulated deficit reached $51.7 million at year-end 2025.

Outlook and guidance

  • Existing cash is expected to fund operations into Q1 2027, but only covers preliminary work for a Phase 2b GRI-0621 trial.

  • Substantial additional capital is required to complete a Phase 2b trial and continue development programs.

  • Plans to raise further funds through equity, debt, or strategic partnerships.

Funding plan to complete GRI-0621 Phase 2b trial?
Impact if GRI-0621 505(b)(2) pathway is denied?
Remediation plan for new material weakness?
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Q1 202614 May, 2026
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Frequently asked questions

GRI Bio Inc. is a biotechnology company focused on developing therapies for inflammatory, fibrotic, and autoimmune diseases. The company specializes in modulating natural killer T (NKT) cells to target immune system dysregulation. Its research and development efforts aim to advance novel small-molecule drug candidates for conditions with high unmet medical needs. The company is headquartered in La Jolla, California, and its shares are listed on the NASDAQ.

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