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GT Biopharma (GTBP) investor relations material

GT Biopharma H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary5 Sep, 2025

Key technology and pipeline updates

  • Developing trispecific killer cell engager camelid nanobodies for cancer and HIV, with a platform adaptable to multiple targets.

  • Currently conducting a Phase 1 trial for blood cancer, specifically acute myeloid leukemia, and planning to file an IND for solid tumors by year-end.

  • Pipeline includes over six candidates, with a focus on expanding into the larger solid tumor oncology market.

Scientific advancements and clinical data

  • TriKE® molecules combine anti-CD16, IL-15, and tumor antigen targeting, enhancing NK cell activation and proliferation.

  • First-generation TriKE® (GTB-3550) showed proof of concept with NK cell expansion and blast reduction in AML patients.

  • Second-generation camelid TriKE® (GTB-3650) demonstrates increased potency and sustained immune activation, with no dose-limiting toxicity observed so far.

Solid tumor and future development plans

  • B7H3 identified as a promising pan-tumor antigen; proprietary camelid TriKE® shows strong preclinical efficacy in eradicating solid tumor masses.

  • Planned basket trial for solid tumors will use subcutaneous outpatient therapy, aiming for FDA submission in the coming months.

  • Seven cohorts will be included to identify responsive tumor types and define the regulatory path over the next few years.

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Q3 202513 Nov, 2025
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Frequently asked questions

GT Biopharma Inc. is a biotechnology company focused on developing immuno-oncology therapies for cancer treatment. The company specializes in TriKE (Tri-specific Killer Engager) technology, which is designed to enhance the ability of natural killer (NK) cells to target and destroy cancer cells. GT Biopharma’s pipeline includes investigational treatments for hematologic malignancies and solid tumors. The company is headquartered in Brisbane, California, and its shares are listed on the NASDAQ.

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