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Humacyte (HUMA) investor relations material

Humacyte Q2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q2 2025 earnings summary11 Aug, 2025

Executive summary

  • Achieved first commercial sales of FDA-approved Symvess in Q2 2025, marking transition to a commercial-stage company and expanding hospital eligibility from 5 to over 200 facilities, including military and civilian sites.

  • Secured ECAT listing from the US Defense Logistics Agency, enabling access to 35 military and 160 VA hospitals, with initial and repeat sales to military facilities.

  • Positive topline results from V007 Phase III trial in AV access for hemodialysis, with data presented at major conferences and accepted for publication.

  • Implemented cost reduction actions in April 2025, including a 30-employee workforce reduction and deferred hiring to extend cash runway.

  • Overcame headwinds from public attacks and challenging economic environment, with commercial momentum accelerating in June and July.

Financial highlights

  • Q2 2025 revenue was $0.3M ($0.1M US sales, $0.2M research collaboration); $0.8M for six months ended 06/30/2025.

  • Net loss for Q2 2025 was $37.7M, improved from $56.7M prior year; net income of $1.5M for six months, versus $88.6M loss prior year, driven by non-cash remeasurement of contingent earn-out liability.

  • R&D expenses: $22M for Q2 2025 (down from $23.8M prior year); $37.4M for six months (down from $45M prior year).

  • SG&A expenses: $7.8M for Q2 2025 (up from $5.7M prior year); $15.9M for six months (up from $11.1M prior year), reflecting commercial launch costs.

  • Cash, cash equivalents, and restricted cash totaled $88.4M as of 06/30/2025; $46.7M raised in March 2025 public offering.

Outlook and guidance

  • Expect continued growth in hospital eligibility and sales, with a focus on high-volume centers and further military facility penetration.

  • Plan to complete VO12 trial enrollment (~150 patients) by year-end 2025, with interim analysis in April 2026 and potential BLA filing in 2026.

  • Anticipate IND filing for coronary artery bypass graft program in late 2025, with clinical trial start in 2026.

  • Management believes available cash and equity facilities will fund operations for at least 12 months; additional capital may be required for long-term operations.

  • Cost reduction actions expected to yield over $50M in savings across 2025–2026.

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Frequently asked questions

Humacyte Inc. is a clinical-stage biotechnology company developing regenerative medicine products. It focuses on bioengineered human tissues and organs for vascular and other applications. The company’s technology platform is designed to produce off-the-shelf, universally implantable tissues. The company is headquartered in Durham, North Carolina, and its shares are listed on the NASDAQ.

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