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I-Mab (IMAB) investor relations material
I-Mab Investor Update summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Investor Update summary16 Oct, 2025
Business transformation strategy
Transitioning to a global biotech platform, leveraging operations in both China and the US to bridge Asian innovation with global markets.
Adopting a hub-and-spoke model to source, develop, and out-license clinical-stage assets, focusing on maximizing value creation at proof-of-concept stages.
Emphasizing capabilities in clinical development, business development, and capital solutions, supported by strong partnerships and investment backing from CBC Group.
Systematic asset screening process, with over 550 opportunities identified and a disciplined approach to deal selection and execution.
Plans to expand into new therapeutic areas, starting with ophthalmology, and targeting 2–4 new molecules per year for the platform.
Pipeline and clinical updates
Lead asset GivaStomach (Claudin 18.2/4-1BB bispecific antibody) shows robust efficacy and favorable safety in early clinical studies for gastric cancer.
A randomized Phase II study for GivaStomach is planned, targeting a broad patient population, with first patient in expected in 2026.
Acquisition of VS-101, a bifunctional biologic for wet AMD and DME, through subsidiary Viscera, with Phase II data expected by end of year and Phase III initiation in 2026.
Additional pipeline assets include a PD-L1/4-1BB bispecific with promising ORR in heavily pretreated patients, and a CD73 antibody in Phase II trials for biomarker-selected populations.
Financial and operational model
Focus on capital efficiency by acquiring clinical-stage assets, advancing them to proof-of-concept, and monetizing through out-licensing, spin-offs, or equity/profit-sharing arrangements.
Typical investment per asset is around $100 million, aiming for significant value creation and potential billion-dollar exits.
Hub-and-spoke structure allows scientific autonomy at the asset level, with centralized support for business development and strategic partnerships.
Dual listing on Nasdaq and Hong Kong planned to strengthen balance sheet and access broader capital markets.
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Q3 202513 Nov, 2025
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Frequently asked questions
I-Mab is a clinical-stage biopharmaceutical company focused on the discovery, development, and potential commercialization of innovative biologics, particularly in the fields of immuno-oncology and immuno-inflammation. The company has a diverse pipeline, including several antibody-based therapies aimed at treating various forms of cancer. These include drugs in different phases of clinical trials, such as Uliledlimab for solid tumors and Lemzoparlimab for hematologic malignancies. The company is headquartered in Rockville, Maryland, and its shares are listed on the NASDAQ.
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