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iBio (IBIO) investor relations material
iBio Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025
Business overview and pipeline focus
Focused on antibody discovery for obesity and cardiometabolic diseases, targeting gaps left by GLP-1 therapies.
Lead program, IBIO-610, is a long-acting Activin E antibody with up to 100-day predicted human half-life, aiming for twice-yearly dosing.
IND equivalent filing in Australia planned for end of 2026, with first patient dosing in 2027.
Pipeline includes Amylin and myostatin programs, with unique selectivity and potential for combination regimens.
Portfolio approach addresses fat loss, muscle preservation, and weight maintenance.
Technology and discovery platform
Integrates generative AI with wet lab biology for antibody discovery and optimization.
Epitope engineering engine targets specific protein regions, improving antibody specificity and developability.
Single-shot multidimensional optimization combines AI and mammalian display to select optimal clones.
Platform enabled creation of the only Activin E antibody to date.
Clinical and regulatory strategy
Australia chosen for initial IND due to faster acceptance, suitable population, and tax incentives; U.S. IND to follow.
Non-human primate data prioritized for partner discussions and de-risking; phase I trials to focus on safety and early efficacy signals.
Phase Ia trial for IBIO-610 planned as dose escalation with 3-4 cohorts, leveraging learnings from other long-acting modalities.
Myostatin program (IBIO-600) expected to file and dose first patient in first half of next year.
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Q2 20269 Feb, 2026
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Frequently asked questions
Bio iBionext, Inc., provides contract development and manufacturing services to collaborators and third-party customers in the United States. The company offers development and manufacturing services for pharmaceuticals; laboratory research and diagnostics; protein research, engineering, and discovery; cell culture media products; pathogen detection; and bioproduction, packaging, and validation services. It sources raw materials from commercial suppliers primarily in North America. The company was founded in 1983 and is based in Westlake Village, California.
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