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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
Idorsia (IDIA) investor relations material
Idorsia Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary2 Dec, 2025
Company background and pipeline
Founded in 2017, leveraging a legacy R&D team and pipeline dating back to 1997.
Three approved products: Clazosentan (Asia), Daridorexant/QUVIVIQ (13 countries), and Aprocitentan (US/EU).
Three phase 3 assets, including two partnered with Viatris and one (Lucerastat) for Fabry disease.
QUVIVIQ (Daridorexant) market performance and strategy
QUVIVIQ is recognized as best-in-class among DORAs due to rapid clearance and minimal next-day grogginess.
Launched in 2023, initially led NBRX with strong detailing and promotional campaigns.
Faced challenges in the US due to payer negotiations, late market entry, and Schedule IV status.
Shifted to a limited omnichannel model in late 2024, stabilizing revenues and improving paid prescriptions.
Awaiting a class-wide descheduling decision, which could expand access and retail pharmacy availability.
Regulatory and competitive landscape
FDA analysis for descheduling is complete; currently in HHS clearance before DEA review and public comment.
Class-wide descheduling effort is in collaboration with Eisai; all DORAs remain Schedule IV.
DORAs represent less than 2% of US insomnia prescriptions, but up to 30% in Japan and 5% in some European countries.
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Q4 202526 Feb, 2026
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Frequently asked questions
Idorsia Ltd is a biopharmaceutical company based in Switzerland, specializing in the discovery, development, and commercialization of small molecules. The company targets a wide range of diseases, including Fabry disease, insomnia, resistant hypertension, cerebral vasospasm, epilepsy, nasal polyposis, and systemic lupus erythematosus, among others. Idorsia's approach spans multiple therapeutic areas such as CNS, cardiovascular, and immunological disorders, as well as orphan diseases. The company is headquartered in Allschwil, near Basel, Switzerland, and its shares are listed on the SIX Swiss Exchange.
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