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Immatics (IMTX) investor relations material
Immatics Q2 2026 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Enrollment in the SUPRAME Phase 3 trial for anzu-cel remains on track, with final PFS analysis expected in H1 2027 and BLA submission planned for 2027.
Updated Phase 1b data for anzu-cel in metastatic melanoma showed 56% confirmed ORR, 14.6 months mDOR, 6.1 months mPFS, and 16.2 months mOS, with a 2-year OS rate of 46%.
IMA203CD8 demonstrated 63% ORR and 50% confirmed ORR in gynecologic cancers, supporting broad applicability across solid tumors.
IMA402 bispecific therapy advanced to Phase 1b, with data across multiple cancers to be presented at ESMO Congress 2026.
Cash position of $448.2 million as of June 30, 2026, with cash reach projected into 2028.
Financial highlights
Cash and cash equivalents plus other financial assets totaled $448.2 million as of June 30, 2026, down from $534.7 million at year-end 2025.
Revenue for Q2 2026 was $10.4 million, up from $5.4 million in Q2 2025, driven by increased collaboration activity.
R&D expenses rose to $71.1 million in Q2 2026 from $51.4 million in Q2 2025, mainly due to clinical trial advancement.
Net loss for Q2 2026 was $71.2 million, an improvement from $80.1 million in Q2 2025, primarily due to lower non-cash FX losses and higher revenue.
Outlook and guidance
SUPRAME Phase 3 trial enrollment to complete by year-end 2026, with topline PFS data in H1 2027.
BLA submission for anzu-cel planned for 2027, with commercial infrastructure preparations underway.
Additional data from IMA203CD8 and IMA402 expected at ESMO Congress 2026; first combination data for IMA402/IMA401 in sqNSCLC anticipated in 2027.
- IMA203 demonstrated strong and durable responses in advanced melanoma with manageable safety.IMTX
Clinical Data Presentation - Q1 2026 net loss of $66.5M, $521.5M cash, and key PRAME clinical milestones set for 2026.IMTX
Q1 2026 - PRAME cell therapy pipeline advanced, revenue fell, and cash runway extended to 2028.IMTX
Q4 2025 - Biotech seeks up to $500M for TCR immunotherapy R&D, with $150M at-the-market via Leerink Partners.IMTX
Registration Filing - Advanced PRAME therapies and bispecifics, but higher R&D costs led to a larger net loss.IMTX
Q3 2025 - PRAME-targeted therapies deliver robust, durable responses and are advancing toward broad commercialization.IMTX
Investor Presentation - IMA402 and IMA401 bispecifics show strong safety and efficacy in advanced solid tumors.IMTX
Study Update - A 54% response rate and 6-month median PFS were achieved in advanced melanoma.IMTX
Study Update - TCR-T therapy achieved 55% response in melanoma; pivotal trial and new data expected this year.IMTX
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