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Immunome (IMNM) investor relations material

Immunome H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025

Strategic vision and leadership

  • Focus on building a premier oncology company with a robust pipeline of targeted therapies for cancer, including gamma secretase inhibitors and ADCs.

  • Leadership team includes experienced professionals with a track record in successful drug development.

  • Emphasis on both internal discovery and disciplined business development to drive innovation.

  • Long-term goal is to deliver transformative cancer drugs to patients globally.

Pipeline highlights and clinical progress

  • Varigastat, a once-daily gamma secretase inhibitor for desmoid tumors, is in phase 3 with top-line data expected in the second half of the year.

  • Phase 2 data for varigastat showed higher potency and better response rates compared to the current standard, with a favorable safety profile.

  • The phase 3 trial is randomized, double-blind, and placebo-controlled, with key endpoints including PFS and ORR.

  • Regulatory guidance and event-driven unblinding strategies are being followed for data disclosure.

ADC technology and innovation

  • First ADC candidate, targeting ROR1 (IM-1021), leverages proprietary payload and rapid internalization for enhanced efficacy.

  • Preclinical and early clinical data show strong activity in both B-cell lymphomas and solid tumors.

  • ADC platform uses a novel topo I inhibitor payload (HC-74) designed to overcome resistance and improve therapeutic index.

  • Three additional ADCs are expected to be filed as INDs in 2026, with a focus on unique, underexploited targets.

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Frequently asked questions

Immunome, Inc. is a biotechnology company focused on developing targeted cancer therapies. The company leverages a proprietary discovery platform to identify novel antigens and develop corresponding therapies, particularly in the field of oncology. Immunome's product pipeline includes several candidates, such as AL102, a gamma secretase inhibitor currently in Phase 3 trials for the treatment of desmoid tumors, and other preclinical assets aimed at targeting specific cancer markers through various therapeutic approaches, including antibody-drug conjugates (ADCs) and radioligand therapies. The company is headquartered in Bothell, Washington, and its shares are listed on the NASDAQ.

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