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Immunome (IMNM) investor relations material
Immunome H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Strategic vision and leadership
Focus on building a premier oncology company with a robust pipeline of targeted therapies for cancer, including gamma secretase inhibitors and ADCs.
Leadership team includes experienced professionals with a track record in successful drug development.
Emphasis on both internal discovery and disciplined business development to drive innovation.
Long-term goal is to deliver transformative cancer drugs to patients globally.
Pipeline highlights and clinical progress
Varigastat, a once-daily gamma secretase inhibitor for desmoid tumors, is in phase 3 with top-line data expected in the second half of the year.
Phase 2 data for varigastat showed higher potency and better response rates compared to the current standard, with a favorable safety profile.
The phase 3 trial is randomized, double-blind, and placebo-controlled, with key endpoints including PFS and ORR.
Regulatory guidance and event-driven unblinding strategies are being followed for data disclosure.
ADC technology and innovation
First ADC candidate, targeting ROR1 (IM-1021), leverages proprietary payload and rapid internalization for enhanced efficacy.
Preclinical and early clinical data show strong activity in both B-cell lymphomas and solid tumors.
ADC platform uses a novel topo I inhibitor payload (HC-74) designed to overcome resistance and improve therapeutic index.
Three additional ADCs are expected to be filed as INDs in 2026, with a focus on unique, underexploited targets.
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