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Immunome (IMNM) investor relations material
Immunome Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary3 Dec, 2025
Key accomplishments and milestones in 2025
Brought AL102 into the portfolio in early 2024 and guided toward top-line data by end of 2025.
Filed IND for IM1021, the first ADC, at the end of 2024; ran clinical trials and IND-enabling work for next ADCs throughout 2025.
Disclosed initial activity for IM1021 and positioned for potential NDA submission and commercial launch in 2026.
Advanced additional ADC programs toward the clinic, with multiple INDs expected in 2026.
AL102 phase 3 trial and differentiation
Anticipated phase 3 data for AL102 by end of 2025, with focus on objective response rate and tumor volume reduction as key differentiators from OGSIVEO.
Phase 2 data showed 64% objective response rate and 88% median tumor volume reduction, compared to OGSIVEO's 41% and 59%, respectively.
Secondary endpoints like T2-weighted imaging are important for physicians and may be highlighted in future conference presentations.
Top-line press release will include essential secondary endpoints, balancing disclosure with the need for impactful conference presentations.
Clinical trial design and market opportunity
RINGSIDE trial uses radiographic progression for primary endpoint, considered more rigorous than OGSIVEO's composite endpoint.
Differences in progression definitions have subtle impact on primary endpoint, with secondary endpoints defined identically.
A "win" is defined as a clearly superior drug profile compared to OGSIVEO, not just a marginal improvement in response rate.
Desmoid tumor market is in early stages, with significant opportunity to displace surgery and expand systemic treatment options.
AL102: How to expand desmoid tumor market?
ADC platform: How does HC-74 overcome resistance?
IM1021: How does safety compare to Merck's ROR1?
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Next Immunome earnings date
Q4 202516 Mar, 2026
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Frequently asked questions
Immunome, Inc. is a biotechnology company focused on developing targeted cancer therapies. The company leverages a proprietary discovery platform to identify novel antigens and develop corresponding therapies, particularly in the field of oncology. Immunome's product pipeline includes several candidates, such as AL102, a gamma secretase inhibitor currently in Phase 3 trials for the treatment of desmoid tumors, and other preclinical assets aimed at targeting specific cancer markers through various therapeutic approaches, including antibody-drug conjugates (ADCs) and radioligand therapies. The company is headquartered in Bothell, Washington, and its shares are listed on the NASDAQ.
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