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Intellia Therapeutics (NTLA) investor relations material
Intellia Therapeutics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary7 Aug, 2025
Executive summary
Achieved or exceeded all operational and clinical objectives for H1 2025, with accelerated enrollment in all three Phase 3 studies and plans to expand the MAGNITUDE study to 1,200 patients.
Lead in vivo programs for ATTR amyloidosis and HAE are in Phase 3, progressing ahead of schedule, with strong clinical data showing a 98% reduction in HAE attacks and deep, durable TTR reduction in ATTR patients.
Strategic restructuring in January 2025 prioritized core programs, reduced workforce by 27%, and included real estate consolidation.
Expanded commercial and medical affairs leadership teams to support anticipated product launches and commercial readiness.
Announced planned retirement of Chief Medical Officer, with succession planning underway.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $630.5M as of 06/30/2025, down from $861.7M at 12/31/2024, reflecting $65M in non-recurring payments for restructuring and real estate.
Collaboration revenue rose to $14.2M in Q2 2025 from $6.9M in Q2 2024, mainly due to Regeneron cost reimbursements.
R&D expenses decreased to $97M in Q2 2025 from $114.2M in Q2 2024, driven by lower employee and stock-based compensation costs.
G&A expenses fell to $27.2M in Q2 2025 from $31.8M in Q2 2024, with lower stock-based compensation partially offset by commercial build-out costs.
Net loss narrowed to $101.3M in Q2 2025 from $147.0M in Q2 2024.
Outlook and guidance
Cash runway expected to fund operations into the first half of 2027 and through the anticipated first commercial launch.
MAGNITUDE trial enrollment to reach at least 650 patients by year-end 2025, with expansion to 1,200 pending regulatory review.
HAELO study randomization to complete in Q3 2025; BLA submission for lonvo-z planned for H2 2026.
Expenses projected to decrease in 2025 due to portfolio prioritization and restructuring.
Additional clinical data readouts for lonvo-z and nex-z expected in H2 2025.
Assess impact of MAGNITUDE expansion on timelines.
When is the BLA submission for lonvo-z expected?
Elaborate on commercial team buildout rationale.
What is the strategic rationale for ATTR-CM study expansion?
Lonvo-z: Payer reaction to one-time HAE therapy?
Nex-z: Impact of new RNAi on commercial positioning?
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Next Intellia Therapeutics earnings date
Q3 20256 Nov, 2025
Next Intellia Therapeutics earnings date
Q3 20256 Nov, 2025
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Frequently asked questions
Intellia Therapeutics, Inc., a genome editing company, focuses on the development of therapeutics. The company's therapies are based on a targeted genome editing platform, including CRISPR/Cas9 and proprietary next-generation programmable nucleases (PNs), which can induce a range of large deletions, substitutions or insertions across a target gene. The CRISPR/Cas9 genome editing technology has been shown to be effective in editing genomes in multiple cell types and organisms. Intellia Therapeutics was founded in 2013 and is based in Cambridge, Massachusetts.
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