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Iovance Biotherapeutics (IOVA) investor relations material
Iovance Biotherapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Product portfolio and approvals
Two approved products: Amtagvi (lifileucel) for advanced post-PD-1 melanoma and Proleukin, an IL-2 analog used in the treatment regimen.
Amtagvi is the first FDA-approved T-cell therapy for solid tumors, with recent approvals in the U.S. and Canada.
Planning for further approvals in the EU, UK, Australia, and Switzerland.
Clinical development and pipeline
Expanding Amtagvi to new indications, notably non-small cell lung cancer (NSCLC) and endometrial cancer, with pivotal studies ongoing.
Advancing to earlier lines of therapy, including frontline melanoma in combination with pembrolizumab (TIL1301 trial).
Developing next-generation TIL therapies, such as PD-1 inactivated TIL and IL-12 tethered TIL, with clinical and preclinical progress expected this year.
Market opportunity and patient access
U.S. market potential for Amtagvi exceeds $1 billion, with significant unmet need in melanoma, NSCLC, and endometrial cancer.
Initial U.S. melanoma target population is about 8,000 patients annually, with global expansion targeting up to 70,000 patients.
Over 250 million patient lives covered by insurance; more than 75% of patients have private insurance.
80 authorized treatment centers in the U.S., with most patients living within 200 miles of a center.
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