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Iovance Biotherapeutics (IOVA) investor relations material

Iovance Biotherapeutics H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025

Product portfolio and approvals

  • Two approved products: Amtagvi (lifileucel) for advanced post-PD-1 melanoma and Proleukin, an IL-2 analog used in the treatment regimen.

  • Amtagvi is the first FDA-approved T-cell therapy for solid tumors, with recent approvals in the U.S. and Canada.

  • Planning for further approvals in the EU, UK, Australia, and Switzerland.

Clinical development and pipeline

  • Expanding Amtagvi to new indications, notably non-small cell lung cancer (NSCLC) and endometrial cancer, with pivotal studies ongoing.

  • Advancing to earlier lines of therapy, including frontline melanoma in combination with pembrolizumab (TIL1301 trial).

  • Developing next-generation TIL therapies, such as PD-1 inactivated TIL and IL-12 tethered TIL, with clinical and preclinical progress expected this year.

Market opportunity and patient access

  • U.S. market potential for Amtagvi exceeds $1 billion, with significant unmet need in melanoma, NSCLC, and endometrial cancer.

  • Initial U.S. melanoma target population is about 8,000 patients annually, with global expansion targeting up to 70,000 patients.

  • Over 250 million patient lives covered by insurance; more than 75% of patients have private insurance.

  • 80 authorized treatment centers in the U.S., with most patients living within 200 miles of a center.

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Frequently asked questions

Iovance Biotherapeutics Inc is a biotechnology company focused on developing cell-based immunotherapies for the treatment of cancer. The company specializes in tumor-infiltrating lymphocyte (TIL) therapies, which involve harnessing and enhancing a patient's immune cells to target and destroy cancer cells. Iovance’s research primarily targets solid tumors, aiming to offer new treatment options for patients with melanoma, cervical cancer, and other types of cancers. Its therapies are developed using advanced cell therapy technologies to address cancers that are resistant to traditional treatments. The company is headquartered in San Carlos, California, and its shares are listed on the NASDAQ.

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