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Perspective Therapeutics
Perspective Therapeutics (CATX) investor relations material
Perspective Therapeutics 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary14 Jan, 2026
Patient impact and clinical results
Demonstrated significant tumor reduction in neuroendocrine cancer patients using VMT-α-NET, with some achieving near-complete responses after four doses.
Achieved a 44% overall response rate and 81% progression-free survival at one year in SSTR2-positive tumors, with a strong safety profile and no serious adverse events.
Melanoma program showed prolonged disease stability at 3-millicurie dose, with no major adverse events and potential synergy with checkpoint inhibitors.
FAP-α program targets a broad range of solid tumors, leveraging high tumor retention and rapid accumulation for effective stroma targeting.
Imaging with lead-203 enables precise patient selection and dosimetry, optimizing therapeutic outcomes and minimizing off-target effects.
Technology and platform differentiation
Utilizes a proprietary chelator and peptide-based delivery system for lead-212, optimizing biodistribution and minimizing kidney uptake.
Lead-212 offers a potent, short-lived alpha payload with a 10-hour half-life, balancing efficacy and safety while enabling same-day delivery.
Elemental twin lead-203 allows for pre-therapy imaging, ensuring accurate targeting and patient selection.
Platform supports multiple programs, including SSTR2, MC1R, and FAP-α, with a robust pipeline and ongoing first-in-human studies.
IP portfolio covers composition of matter, chelator technology, and scalable manufacturing processes.
Manufacturing, supply chain, and scalability
Vertically integrated model covers discovery, clinical development, isotope production, and commercial manufacturing.
End-to-end manufacturing network with facilities in New Jersey, Iowa, and expansion into Chicago, Houston, and LA ensures reliable supply.
Stockpiles thorium-228, enabling years of uninterrupted isotope supply and reducing risk of shortages.
Same-day shelf life for lead-212 products necessitates a distributed network for timely delivery to hospitals.
Collaboration with the U.S. Department of Energy and international partners secures upstream isotope sources.
How does VMT-alpha-NET's safety compare to others?
Explain the Lead-203/212 theranostic advantage
How does Thorium-228 stockpile mitigate supply risk?
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Next Perspective Therapeutics earnings date
Q4 202527 Mar, 2026
Perspective Therapeutics
Next Perspective Therapeutics earnings date
Q4 202527 Mar, 2026
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Frequently asked questions
Perspective Therapeutics Inc (formerly Isoray, Inc.) is a medical technology and radiopharmaceutical company that is pioneering advanced treatment applications for cancers throughout the body. The Company is the sole producer of Cesium-131 brachytherapy seeds and has a proprietary technology that utilizes the isotope lead-212 to deliver powerful alpha radiation specifically to cancer cells via specialized targeting peptides. The Company is also developing complementary imaging diagnostics that incorporate the same targeting peptides which provide the opportunity to personalize treatment and optimize patient outcomes. This “theranostic” approach enables the ability to see the specific tumor and then treat it to potentially improve efficacy and minimize toxicity associated with many other types of cancer treatments. The Company’s melanoma (VMT01) and neuroendocrine tumor (VMT-a-NET) programs are entering Phase 1/2a imaging and therapy trials for the treatment of metastatic melanoma and neuroendocrine tumors at several leading academic institutions. The Company has also developed a proprietary lead-212 generator to secure isotope supply for clinical trial and commercial operations. In 2023 Isoray, Inc., a medical technology company and innovator in seed brachytherapy, completed its merger with privately-held Viewpoint Molecular Targeting, Inc. The combined companies’ focus will be the advancement of cancer treatments using radiation, radiopharmaceuticals, and imaging technologies so that precision, targeted medical doses are delivered directly to cancer patient tumor sites.
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