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Investor Relations14 Oct 2025
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Jasper Therapeutics (JSPR) investor relations material
Jasper Therapeutics Cantor Global Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Cantor Global Healthcare Conference 2025 summary3 Sep, 2025
Company overview and lead asset
Clinical-stage biotech focused on monoclonal antibody briquelimab (BRIC), targeting KIT on mast cells for urticaria treatment.
Briquelimab was originally developed by Amgen for pulmonary fibrosis but repurposed for urticaria due to mast cell involvement.
Mast cells are central to urticaria pathology; targeting KIT induces mast cell apoptosis, providing extended clinical benefit.
Competitive landscape and mechanism of action
Only anti-KIT antibodies like briquelimab deplete mast cells; small molecule inhibitors only suppress activity, not cell numbers.
Small molecule KIT inhibitors have not demonstrated mast cell depletion, with symptoms returning as drug levels fall.
Achieving sufficient intracellular concentration for depletion with small molecules remains a challenge.
Clinical trial design and dosing insights
BEACON study explores multiple dosing regimens; optimal appears to be 180 mg every 8 weeks, yielding rapid and sustained symptom relief.
120 mg dose effective but requires more frequent dosing; higher doses (240 mg, 360 mg) do not show added benefit and may increase adverse events.
Open label extension (OLE) allows patients to re-enter after disease recurrence, providing long-term efficacy and safety data.
What caused the confounding results in Cohorts 8/9?
Differentiate BRIC efficacy vs. Barzolumab
Which dosing regimen for Phase 2b study?
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Next Jasper Therapeutics earnings date
Q3 20257 Nov, 2025
Next Jasper Therapeutics earnings date
Q3 20257 Nov, 2025
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Leroy DaleyApp Store
One of the very few apps you could call perfect. If something was to add to it, maybe the share price of the company when you search for it, but it's already excellent.
Eferix Drawings Google Play
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Amina0781App Store
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Frequently asked questions
Jasper Therapeutics, Inc. is a clinical-stage biotechnology company specializing in the development of therapeutic agents primarily for hematopoietic stem cell transplantation and gene therapies. The company is focused on advancing novel therapeutic agents intended for a variety of applications, including conditions like chronic spontaneous urticaria and lower to intermediate risk myelodysplastic syndromes. Additionally, Jasper Therapeutics is developing new conditioning regimens for stem cell transplantation and ex-vivo gene therapy, which involves the genetic manipulation of cells outside the body before transplantation. Their leading product candidate, briquilimab, is designed to clear hematopoietic stem cells from bone marrow to facilitate allogeneic stem cell or gene therapy. The company is headquartered in Redwood City, California, and its shares are listed on the NASDAQ.
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