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Jazz Pharmaceuticals (JAZZ) investor relations material
Jazz Pharmaceuticals Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Strategic vision and corporate overview
Focused on developing innovative, life-changing medicines for serious diseases with limited treatment options.
Mission to transform the lives of patients and their families through novel therapies.
Strong emphasis on operational excellence and disciplined capital allocation to drive shareholder value.
Commercial execution and product portfolio
Diverse portfolio spans neuroscience (sleep, epilepsy) and oncology, with leading products like Xywav, Epidiolex, Zepzelca, Rylaze, and Modeyso.
Xywav is the #1 branded treatment for narcolepsy and the only approved therapy for idiopathic hypersomnia, with $431M in 3Q25 revenue (11% YoY growth).
Epidiolex is the #1 branded epilepsy treatment, poised to reach blockbuster status in 2025, with $303M in 3Q25 revenue (20% YoY growth).
Zepzelca approved for 1L ES-SCLC maintenance, included in NCCN Guidelines, and showing improved survival in clinical trials.
Rylaze is the standard of care for pediatric ALL/LBL patients with hypersensitivity to E. coli-derived asparaginase.
Modeyso launched as the first and only FDA-approved treatment for recurrent H3 K27M-mutant diffuse midline glioma.
Pipeline and R&D investments
Robust pipeline with key programs: zanidatamab (HER2+ cancers), dordaviprone (glioma), JZP815 (pan-RAF inhibitor), and JZP898 (conditionally-activated IFNa therapy).
Zanidatamab demonstrated positive Phase 3 results in GEA, ongoing launches in BTC, and broad potential in multiple HER2+ tumors.
Dordaviprone in confirmatory Phase 3 ACTION study for H3 K27M-mutant diffuse glioma, with interim OS analysis expected late 2026/early 2027.
JZP815 and JZP898 in Phase 1 trials targeting solid tumors with MAPK pathway alterations and advanced solid tumors, respectively.
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