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Krystal Biotech (KRYS) investor relations material
Krystal Biotech Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary3 Dec, 2025
Business overview and recent performance
VYJUVEK is the first genetic medicine approved for at-home dosing, with launches in the U.S., France, Germany, and Japan.
Manufacturing, shipping, and packaging processes are fully controlled, supporting future pipeline scalability.
Financial position is strong, with positive EPS for the last eight to nine quarters and a robust balance sheet.
U.S. VYJUVEK business and growth outlook
Steady state compliance is expected, but not within the next 12 months; recent label changes are a tailwind.
Steady state is defined as 26–30 vials per patient annually, with an average price of $450,000–$500,000 per patient.
Over 615 patients are on therapy, targeting 1,200 identified patients, with a total prevalence of 3,000.
International expansion and pricing
Japan pricing is close to U.S. net pricing, with only a 23% WAC discount, indicating strong value.
European pricing outlook is optimistic, with analogs in enzyme/protein replacement drugs.
Ex-U.S. launches are expected to be underestimated, with Japan already exceeding typical revenue ratios.
OUS and U.S. sales will be broken out once ex-U.S. becomes material; patient ramp-up will be disclosed directionally.
What drives confidence in OUS sales exceeding US?
What's the strategic basis for ocular DEB study design?
What makes Hailey-Hailey a compelling pipeline asset?
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Next Krystal Biotech earnings date
Q4 202513 Feb, 2026
Next Krystal Biotech earnings date
Q4 202513 Feb, 2026
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Frequently asked questions
Krystal Biotech Inc., known as Krystal Biotech, is a biotechnology firm engaged in the development and commercialization of genetic medicines targeting rare and serious diseases. The company focuses on creating treatments using gene therapy approaches, with a significant emphasis on dermatological conditions. Its product pipeline includes innovative therapies such as bercolagene telserpavec (B-VEC) for dystrophic epidermolysis bullosa, a severe skin disorder, and other treatments targeting conditions like autosomal recessive congenital ichthyosis and aesthetic skin conditions. Utilizing its proprietary skin TARgeted Delivery (STAR-D) platform, Krystal Biotech aims to advance treatments for various skin diseases, leveraging gene therapy's potential to offer long-term solutions. The company is headquartered in Pittsburgh, Pennsylvania, and its shares are listed on the NASDAQ under the ticker symbol KRYS.
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