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Kymera Therapeutics (KYMR) investor relations material
Kymera Therapeutics TD Cowen Immunology and Inflammation Summit summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Platform and pipeline overview
Degrader platform enables targeting of high-priority, difficult-to-drug targets, with five programs advanced to the clinic in five years.
Focus has shifted toward building a best-in-class oral immunology pipeline, with STAT6 and IRF5 as flagship programs.
STAT6 program completed healthy volunteer study and phase 1B AD dosing, with data to be shared next month; phase 2B AD and asthma studies are underway or planned.
IRF5 program completed IND-enabling studies, moving into phase 1 early next year with data expected in the same year.
Cash runway extends into the second half of 2028, supporting key milestones for STAT6, IRF5, and new programs.
Clinical development and data translation
High-fidelity translation from healthy volunteers to patients is expected based on prior program experience.
Phase 1B aims to confirm translation of safety, PK, and PD (STAT6 degradation) in blood and skin, informing phase 2B dose selection.
STAT6 degrader achieves maximal blood degradation within 4–8 hours, with pathway inhibition kinetics similar to DUPI.
TARC reduction is used as a PD marker, with % reduction dependent on baseline levels; DUPI-like effects are anticipated.
EASI and TARC show moderate correlation; phase 1B aims for activity at day 28 comparable to DUPI's results.
Dose selection and trial design
Phase 2B dose selection is based on extensive phase 1A data, with phase 1B providing translation confirmation.
Three dose levels in phase 2B are designed to cover optimal, supermaximal, and submaximal degradation.
The same dose range will be tested in both AD and asthma phase 2B studies; final phase 3 dose may differ.
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