Lantheus
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Lantheus (LNTH) investor relations material

Lantheus Q4 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q4 2025 earnings summary26 Feb, 2026

Executive summary

  • Achieved $1.546 billion in full-year 2025 revenue, up 0.5% year-over-year, with Q4 revenue of $406.8 million, up 4% year-over-year.

  • Completed acquisitions of Neuraceq/Life Molecular Imaging and OCTEVY/Evergreen Theragnostics, diversifying the radiodiagnostic portfolio.

  • Divested legacy SPECT business effective January 1, 2026, sharpening focus on innovative PET radiodiagnostics.

  • Advanced multiple late-stage pipeline assets toward FDA review in 2026, with up to four potential approvals.

  • Repurchased $100 million in shares in Q4, with $300 million spent on buybacks in 2025 and $359.1 million cash at year-end.

Financial highlights

  • PYLARIFY generated $240.2 million in Q4 revenue (down 9.7% YoY); full-year revenue was $989.1 million (down 6.5%).

  • DEFINITY sales were $85.3 million in Q4 (down 1% YoY) and $330.2 million for the year (up 3.9%).

  • Neuraceq sales reached $31.0 million in Q4 and $51.4 million for the year, emerging as a leading amyloid PET agent.

  • Precision Diagnostics Q4 revenue was $143.2 million, up 22% YoY, driven by Neuraceq.

  • Q4 adjusted EPS was $1.67 (up 4.7% YoY); full-year adjusted EPS was $6.08 (down 10%).

Outlook and guidance

  • FY 2026 revenue guidance: $1.4–$1.45 billion; adjusted diluted EPS guidance: $5.00–$5.25.

  • PYLARIFY net revenue expected to decline 8–10% YoY in 2026, with low single-digit volume growth and modest price erosion.

  • Neuraceq projected to grow 140–150% inorganically in 2026; DEFINITY to grow low to mid-single digits.

  • Up to four FDA approvals anticipated in 2026, with launch readiness for new products and selective advancement of late-stage assets.

  • No significant revenue contribution expected from new launches until 2027.

Elaborate on radiotherapeutic asset alternatives
Why is 2026 revenue guidance lower than 2025?
Future capital allocation strategy for growth?
New PSMA PET formulation launch plan details
PNT2003 patent litigation status
Capital allocation strategy given FCF decline
Detail radiotherapeutic asset value optimization plan
How will PYLARIFY compete post-pass-through loss?
What are key drivers for Neuraceq's 2026 growth?
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Next Lantheus earnings date

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TD Cowen 46th Annual Health Care Conference3 Mar, 2026
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TD Cowen 46th Annual Health Care Conference3 Mar, 2026

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Frequently asked questions

Lantheus Holdings Inc. is a healthcare company specializing in diagnostic imaging and therapeutic solutions. The company develops and commercializes radiopharmaceuticals, contrast agents, and medical imaging products used in cardiology, oncology, and other critical care applications. Lantheus serves healthcare providers, hospitals, and imaging centers, focusing on technologies that enhance disease detection and patient management. Its portfolio includes products for nuclear medicine, ultrasound, and precision diagnostics. The company is headquartered in Bedford, Massachusetts, and its shares are listed on the NASDAQ.

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