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Lisata Therapeutics (LSTA) investor relations material
Lisata Therapeutics Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Company overview and leadership
Clinical-stage pharmaceutical company focused on innovative therapies for cancer and serious diseases.
Mission to rapidly develop and commercialize treatments that improve patient outcomes.
Seasoned management team with global drug development and approval experience.
Proprietary technology with global IP protection extending beyond 2040.
Cash runway extends into Q1 2027 with no debt.
Therapeutic focus and scientific rationale
Solid tumors represent over 90% of diagnosed cancers, with high unmet need in pancreatic cancer.
Certepetide (iRGD peptide) targets and penetrates tumor stroma, enhancing drug delivery and modifying the tumor microenvironment.
Demonstrated ability to deplete immunosuppressive T cells and recruit cytotoxic T cells.
Broad preclinical evidence of improved survival and tumor response across multiple cancer types.
Strong IP portfolio with orphan drug designations and market exclusivity in US/EU.
Clinical results and development progress
Two Phase 1b/2a trials in metastatic PDAC showed improved overall survival with certepetide plus standard chemotherapy.
ASCEND Phase 2b trial: Cohort A showed numerically higher OS (12.68 vs 9.23 months); Cohort B mPFS neared statistical significance (7.46 vs 5.29 months, HR 0.61, p=0.09).
Certepetide demonstrated a benign safety profile, with adverse events consistent with companion therapies.
Early clinical data in combination with immunotherapy (durvalumab) in locally advanced PDAC showed high response and disease control rates.
Evidence of activity in other solid tumors, including sustained complete response in metastatic gastroesophageal adenocarcinoma.
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