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Lyell Immunopharma (LYEL) investor relations material

Lyell Immunopharma H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary10 Sep, 2025

Key program updates and clinical progress

  • Lead program is a dual-targeting CD19/20 CAR T cell therapy, now named RondaCell, for relapsed/refractory large B-cell lymphoma.

  • Pivotal single-arm study underway for third-line approval; phase 3 randomized head-to-head trial launching in second line.

  • RondaCell showed 88% overall response and 70% complete response rates in third-line patients.

  • Six-month complete response rate reached 71%, surpassing benchmarks set by current CD19 CARs.

  • Broader patient inclusion in trials, including older and high-risk populations.

Competitive landscape and differentiation

  • Dual-targeting CD19/20 CARs are outperforming single-target CD19 CARs in response rates and durability.

  • RondaCell uses a single tandem CAR with full potency for both antigens and a 4-1BB domain, linked to lower neurotoxicity.

  • Unique enrichment for naïve central memory T cells, associated with better outcomes and persistence.

  • Lower rates of CRS and neurotoxicity compared to competitors; proactive safety measures implemented.

  • Confident in leadership position, being first to two pivotal trials and a head-to-head study.

Market strategy and commercialization plans

  • Third-line setting seen as both a commercial opportunity and a regulatory bridge to second line.

  • Strategic selection of clinical trial sites to facilitate rapid commercial adoption.

  • Manufacturing capacity supports up to 1,200 doses per year, enabling independent launch.

  • Open to future partnerships, especially for ex-U.S. markets, but no urgency due to current resources.

  • Expectation that CD19/20 CARs will disrupt and potentially replace current CD19 therapies.

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Frequently asked questions

Lyell Immunopharma Inc is a biotechnology company focused on developing cell-based immunotherapies for cancer treatment. The company specializes in genetically engineering T cells to enhance their persistence, potency, and functionality against solid tumors. Lyell Immunopharma conducts research and development activities in collaboration with academic and industry partners. The company is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.

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