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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
MacroGenics (MGNX) investor relations material
MacroGenics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary4 Dec, 2025
Strategic program updates
Discontinued lorigerlimab in prostate cancer after interim phase 2 data failed to meet efficacy thresholds; focus shifted to ovarian and clear cell gynecological cancers.
LINET study for lorigerlimab in gynecologic cancers is ongoing, with international sites and updates expected mid-next year.
Emphasis on dual-positive T-cell targeting and improved safety profile over traditional PD-1/CTLA-4 combinations.
Exploring combination strategies with ADCs and checkpoint inhibitors to enhance efficacy and safety.
Broader franchise strategy includes potential expansion into immunologically sensitive tumor types.
ADC pipeline and development
B7H3 ADC program leverages Synaffix platform for improved safety and efficacy, with two expansion cohorts in solid tumors underway.
ADAM9 ADC program advanced to a second-generation molecule (O28) with no observed ocular toxicity, targeting GI and other solid tumors.
Third ADC targets an undisclosed antigen, aiming for first-in-class status with IND planned for next year.
Combination regimens under consideration, including with T cell engagers and PARP inhibitors.
Clinical data for first two ADCs anticipated next year, with ongoing dose escalation and expansion.
Financial position and outlook
Q3 cash balance was $146 million, with an additional $75 million from collaborations recognized in Q4.
Cash runway extended into late 2027, supporting execution of clinical and strategic plans.
Well-resourced to deliver on upcoming data inflection points and program milestones.
LORIKEET study's specific rPFS threshold
B7H3 ADC: Differentiated development strategy
ADC platform's key differentiation points
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Next MacroGenics earnings date
Q4 20256 Mar, 2026
Next MacroGenics earnings date
Q4 20256 Mar, 2026
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MacroGenics Inc. is a biopharmaceutical company focused on developing and commercializing antibody-based therapies for the treatment of cancer and other serious diseases. The company's pipeline includes immuno-oncology therapies designed to harness the immune system to target and destroy cancer cells. MacroGenics employs its proprietary antibody platforms to create innovative treatments that address unmet medical needs in oncology and other therapeutic areas. The company is headquartered in Rockville, Maryland, and its shares are listed on the NASDAQ.
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