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MacroGenics (MGNX) investor relations material
MacroGenics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary8 Sep, 2025
Company overview and pipeline
Focuses on next-generation antibodies for cancer, with four clinical-stage programs across three modalities, including ADCs and multi-specific platforms.
Utilizes proprietary DART and Trident platforms for t cell engagers and bispecifics, with some assets partnered with major pharma companies.
Three molecules leverage the Cinefix ADC platform, with broad access due to early adoption and up to seven molecules possible.
Portfolio includes both proprietary and partnered programs, with several approved and commercialized molecules.
Cash and marketable securities total $177M, with a runway through 2027, bolstered by a $70M royalty monetization deal.
Key clinical programs and data
Lorigirlimab, a PD-1/CTLA-4 bispecific, is in phase 1 for prostate and gynecologic cancers, showing a 26% ORR and 29% PSA response in late-line prostate cancer.
Durability of response is notable, with some patients maintaining benefit for up to two years.
Safety profile shows fewer severe immune-mediated events compared to traditional CTLA-4 agents, with only 1-2 grade 3 colitis cases in 120+ patients.
Lorikeet study (prostate cancer) is fully enrolled, with a clinical update expected later this year; Lannett study (gynecologic cancers) is ongoing.
ADC programs target B7-H3, ADAM9, and an undisclosed target, with phase 1 studies ongoing and IND submission for O30 planned next year.
Technology and competitive positioning
Cinefix ADC platform enables site-specific conjugation and potent exoticon payload, offering higher potency and less susceptibility to resistance.
Proprietary HydraSpace technology allows conjugation to hydrophobic payloads, improving drug characteristics.
Internal data show strong in vivo efficacy and efficient internalization compared to competitors.
Market validation for the Cinefix linker from other pharma alliances and phase 3 advancement by Innovent.
ADC targets have broad expression across solid tumors, with competitive but non-exclusive market dynamics.
Lorikeet study: What rPFS data defines success?
MGC026: How to differentiate in B7-H3 market?
Partnering strategy: What drives continued deals?
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Next MacroGenics earnings date
Q3 20254 Nov, 2025
Next MacroGenics earnings date
Q3 20254 Nov, 2025
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Frequently asked questions
MacroGenics Inc. is a biopharmaceutical company focused on developing and commercializing antibody-based therapies for the treatment of cancer and other serious diseases. The company's pipeline includes immuno-oncology therapies designed to harness the immune system to target and destroy cancer cells. MacroGenics employs its proprietary antibody platforms to create innovative treatments that address unmet medical needs in oncology and other therapeutic areas. The company is headquartered in Rockville, Maryland, and its shares are listed on the NASDAQ.
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