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Madrigal Pharmaceuticals (MDGL) investor relations material
Madrigal Pharmaceuticals Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary3 Dec, 2025
Year-to-date review and performance
Achieved a billion-dollar run rate with $287.3 million in sales and over 29,500 patients on therapy, indicating strong launch momentum just six quarters in.
Secured robust payer contracting for 2026, ensuring first-line access and improved utilization management.
Advanced pipeline with the acquisition of an oral GLP-1 asset and progress in F4c trials.
Obtained a key Orange Book patent extending exclusivity to 2045.
Clinical data and product positioning
Discontinuation data showed rapid disease return, underscoring the need for chronic therapy and supporting long-term use.
F4 data demonstrated a significant reduction in liver stiffness, especially in sicker populations, de-risking the upcoming MAESTRO-NASH outcomes study.
The F4 cohort's baseline closely matches the ongoing phase 3 program, increasing confidence in future results.
Market expansion and prescriber engagement
Initial focus was on hepatologists, gastroenterologists, and some endocrinologists, with 6,000 high-priority prescribers.
Growing interest from endocrinologists, leading to a dedicated outreach effort starting in Q4, targeting 2,000 high-value endocrinology prescribers.
Endocrinologists interested in MASH and metabolism are proactively seeking education and access to prescribe.
Adoption among endocrinologists is expected to grow gradually as they adapt to new diagnostic and prescribing practices.
Endocrinologist adoption: key hurdles
2026 gross-to-net impact on net revenue
Quantify F4 data's MAESTRO de-risking
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Next Madrigal Pharmaceuticals earnings date
44th Annual J.P. Morgan Healthcare Conference12 Jan, 2026
Next Madrigal Pharmaceuticals earnings date
44th Annual J.P. Morgan Healthcare Conference12 Jan, 2026
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Frequently asked questions
Madrigal Pharmaceuticals Inc. is a biopharmaceutical company focused on the development of therapies for cardiovascular and metabolic diseases. The company specializes in treatments targeting nonalcoholic steatohepatitis (NASH) and other liver-related conditions. Madrigal Pharmaceuticals leverages its expertise in lipid metabolism and endocrinology to advance its pipeline of investigational therapies. The company conducts clinical research to develop novel compounds aimed at addressing unmet medical needs in liver disease and metabolic disorders. Madrigal Pharmaceuticals Inc. is headquartered in West Conshohocken, Pennsylvania, and its shares are listed on the NASDAQ.
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