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Marker Therapeutics (MRKR) investor relations material
Marker Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Technology overview and differentiation
Multi-TAA T-cell technology targets multiple tumor antigens using native T cell receptors, enabling broad recognition of tumor epitopes and engaging both CD4 and CD8 T cells.
Unlike CAR T and bispecific antibodies, this approach is not limited to surface antigens and can target intracellular proteins, expanding the range of treatable cancers.
The natural mechanism of action results in a favorable safety profile, with minimal cytokine release syndrome and neurotoxicity observed in clinical use.
Clinical development and pipeline
Lead asset MT-601 is prioritized for diffuse large B-cell lymphoma (DLBCL), especially in patients relapsed after CAR T and bispecific therapies, addressing a high unmet need.
MT-601 is also being advanced into solid tumors, leveraging its broad target profile and shared development experience.
An off-the-shelf program is planned, with first patient dosing expected in the second half of the year, aiming for rapid and simple patient access.
Clinical trial results and safety
Phase 1 Apollo trial completed dose escalation (100–400 million cells), showing all doses were well tolerated and safe, with a clear efficacy signal.
In 12 non-Hodgkin lymphoma patients, a 50% complete response rate and 66% overall response rate were observed, including strong responses in heavily pretreated DLBCL patients.
Even at the highest dose, safety remains excellent, with only mild, transient cytokine release syndrome and no neurotoxicity.
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