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MBX Biosciences
MBX Biosciences (MBX) investor relations material
MBX Biosciences 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary13 Jan, 2026
Key program updates and milestones
Initiation of confirmatory phase III trial for canvuparatide in Q3, following strong phase II data validating the PEP platform.
Tripling of the obesity portfolio in 2024 with new amycretin and triple agonist candidates, and phase I MAD 12-week data expected in Q4.
Phase II-A proof of concept data for imapextide in post-bariatric hypoglycemia expected in Q2.
Pre-commercial activities underway, including recruitment of a chief commercial officer.
Financial position strengthened by a $200M public offering, ending year with $375M in cash to fund clinical programs.
Technology and clinical differentiation
Precision Endocrine Peptide (PEP) platform uses programmable prodrug and fatty acylation for slow, steady drug release and less frequent dosing.
Prodrug technology allows tuning of release times for different molecules, optimizing tolerability and exposure.
Active peptides are engineered for potency, stability, and multiple mechanisms of action.
Canvuparatide offers an infusion-like PK profile, differentiating it from daily therapies and supporting once-weekly dosing.
Clinical data and market insights
Canvuparatide phase II showed a 63% responder rate at 12 weeks, rising to 79% at six months, with high retention and no treatment-related SAEs.
100% of surveyed patients and 80% of HCPs prefer once-weekly over daily dosing, supporting rapid adoption.
Market research indicates strong physician and patient enthusiasm for weekly administration and switching from daily therapies.
Obesity candidates aim for once-monthly dosing with improved tolerability, addressing GI side effects seen in current therapies.
Imapextide targets post-bariatric hypoglycemia, a sizable and underserved population, with once-weekly dosing.
Canvuparatide: Accelerate market share capture?
Quantify prodrug's tolerability advantage?
Strategic rationale for new obesity targets?
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Next MBX Biosciences earnings date
Q4 202517 Mar, 2026
MBX Biosciences
Next MBX Biosciences earnings date
Q4 202517 Mar, 2026
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Frequently asked questions
MBX Biosciences Inc. is a U.S.-based biotechnology company focused on developing precision medicines for endocrine disorders. The company’s research and development efforts target rare hormonal conditions, with a focus on creating peptide therapies that improve patient outcomes. Leveraging proprietary technology, MBX Biosciences aims to design therapies that address specific needs in endocrinology, including disorders related to hormone deficiencies or imbalances. The company advances its drug candidates through preclinical and clinical stages, seeking to bring effective treatments to patients with unmet medical needs. The company is headquartered in Carmel, Indiana, and its shares are listed on the NASDAQ.
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