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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
Medicenna Therapeutics (MDNA) investor relations material
Medicenna Therapeutics KOL Event summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.KOL Event summary10 Dec, 2025
Introduction and agenda
The event presented updated clinical data from the ABILITY-1 Phase 1/2 study of MDNA11 in advanced solid tumors, including monotherapy and combination with checkpoint inhibitors, and was discussed at ESMO Immuno-Oncology Congress 2025.
The agenda covered trial design, patient characteristics, safety, efficacy, mechanistic insights, future development plans, principal investigator perspectives, KOL commentary, and Q&A.
Webinar hosted with management, principal investigator, and key opinion leaders to discuss results and future directions.
KOL background and credentials
Key opinion leaders included Dr. Hussein Tawbi (MD Anderson), Dr. Igor Puzanov (Roswell Park), Dr. Paolo Ascierto (Naples), Dr. Toni Choueiri (Dana-Farber), and principal investigator Dr. André Mansinho, all with expertise in immuno-oncology and drug development.
Market insights and analysis
MDNA11 is a β-enhanced, not-α IL-2 superagonist in clinical development for advanced solid tumors, with both monotherapy and combination arms (with pembrolizumab/KEYTRUDA).
The molecule's unique receptor engagement and clean safety profile differentiate it from other IL-2 variants, addressing unmet needs in refractory and ICI-resistant solid tumors.
MDNA11 shows durable anti-tumor activity in checkpoint-resistant melanoma, MSS endometrial, MSI-H, and TMB-H cancers, exceeding ORR benchmarks in these populations.
External validation from the NEO-CYT trial in high-risk melanoma supports the approach and potential for earlier-stage patients.
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Next Medicenna Therapeutics earnings date
Q3 202610 Feb, 2026
Next Medicenna Therapeutics earnings date
Q3 202610 Feb, 2026
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Frequently asked questions
Medicenna Therapeutics Corp. is a Canada-based clinical-stage biopharmaceutical company focused on the development of novel immunotherapies for cancer and other diseases. The company’s proprietary platforms are designed to create engineered cytokines, including interleukin-based therapies, aimed at enhancing immune system responses against tumors. The company is headquartered in Toronto, Canada, and its shares are listed on both the NASDAQ and the Toronto Stock Exchange.
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