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Edge31 Oct 2025
Rolls-Royce: Full Thrust Ahead
From century-old crafted perfection to pandemic shock and reset, Rolls-Royce's story is shaped by heritage, turbulence, and a disciplined climb back.
Merck & Co (MRK) investor relations material
Merck & Co Status Update summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Status Update summary10 Nov, 2025
Cardiometabolic and respiratory portfolio advancements
WINREVAIR demonstrated significant reductions in morbidity and mortality for pulmonary arterial hypertension (PAH), with pooled analysis showing a 75% reduction in major morbidity, 56% reduction in lung transplantation or death, and 51% reduction in risk of death.
WINREVAIR is now the first PAH therapy with an indication that includes reduction in hospitalization, lung transplantation, and death.
Ohtuvayre, a first-in-class inhaled therapy for COPD, offers both bronchodilatory and anti-inflammatory effects, with a broad label and positive real-world experience.
Enlicitide: First oral PCSK9 inhibitor
Enlicitide achieved LDL-C reductions of up to 59.7% in the CORALreef Lipids trial and 59.4% in the CORALreef HeFH trial, surpassing other oral lipid-lowering therapies.
Over two-thirds of participants reached rigorous LDL-C goals, with robust reductions in ApoB, non-HDL-C, and Lp(a).
Safety profile was comparable to placebo, with high adherence and no significant adverse drug interactions.
Clinical development and regulatory outlook
CORALreef Lipids and HeFH Phase 3 studies support regulatory filings for enlicitide in early 2026.
Ongoing and future studies include pediatric, combination, and outcomes trials, aiming for broad global access and expanded indications.
How will Enlicitide achieve broad patient access?
WINREVAIR's impact on PAH mortality risk?
Enlicitide's role in future CV combinations
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Next Merck & Co earnings date
7th Annual Healthcare Symposium14 Nov, 2025
Next Merck & Co earnings date
7th Annual Healthcare Symposium14 Nov, 2025
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Frequently asked questions
Over 130 Years of Experience in Healthcare
Merck & Co., commonly known as Merck, is a global pharmaceutical company that specializes in the development and manufacturing of prescription drugs, vaccines, biological therapies, and animal health products. With a storied history dating back over a century, Merck has established itself as a leading player in the healthcare industry. The company's portfolio of products spans various therapeutic areas, including cardiovascular, oncology, infectious diseases, and more.
In business for over a century
Since its establishment in 1891, Merck has played a significant role in advancing medical research and innovation and has a long history of notable contributions to healthcare. They have developed antibiotics like streptomycin, vaccines for diseases such as mumps and HPV, and antiretroviral therapies for HIV/AIDS treatment. Their advancements in cardiovascular medications and statins have significantly impacted heart disease management.
The company today
Today the company focuses on the development, manufacturing, and distribution of a diverse range of prescription drugs, vaccines, and biological therapies. With a commitment to scientific rigor, research, and providing products and medication that improve the lives of ill patients, Merck strives to address various health challenges and contribute to the well-being of individuals globally. Merck is far from being alone when it comes to publicly traded pharmaceutical companies, and some companies that operate in the same space include names such as Pfizer and Eli Lilly.
A diverse portfolio of medications
Merck & Co. develops and manufactures a wide range of medications. Their portfolio of products includes medications for cardiovascular diseases, such as hypertension and hyperlipidemia, as well as anticoagulants and antiplatelet agents. They also offer therapeutics for infectious diseases, including antibiotics, antifungals, and antiviral drugs. In oncology, Merck provides targeted therapies and immunotherapies for different types of cancer. Additionally, they offer medications for diabetes management, respiratory diseases, autoimmune disorders, and more. The company’s flagship medication is Keytruda, which enhances the body’s ability to fight certain types of cancers.
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