Advancing Emi-Le (XMT-1660) for post-topo-1 TNBC, with >40 patients enrolled and initial expansion data expected in 2H 2025.
XMT-2056, a STING-agonist HER2 ADC, is in Phase 1 dose escalation with initial pharmacodynamic data planned for 2025.
Multiple collaborations with GSK, Johnson & Johnson, and Merck KGaA, plus preclinical ADC candidates available for partnering.
Proprietary Dolasynthen and Immunosynthen platforms designed to overcome ADC limitations and expand clinical potential.
Dolasynthen platform offers customizable DAR, reduced toxicities, and controlled bystander effect for enhanced efficacy.
Immunosynthen platform enables tumor-specific STING activation, aiming for potent innate immune stimulation.
Both platforms support monotherapy and combination strategies, with preclinical candidates open for partnerships.
Emi-Le targets B7-H4, a clinically validated marker in TNBC and other tumors, with two FDA Fast Track designations.
Phase 1 dose expansion ongoing in heavily pretreated TNBC patients, all with prior topo-1 ADC exposure.
Safety profile shows no dose-limiting neuropathy, neutropenia, ocular toxicity, ILD, or thrombocytopenia; most TRAEs are low grade and reversible.
Clinical activity correlates with both dose and B7-H4 expression, with ORR up to 29% in B7-H4 high TNBC patients with ≤4 prior lines.
High-dose cohorts suggest a dose-response relationship, with protocol amendments to mitigate proteinuria-related dose delays.
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