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Merus (MRUS) investor relations material
Merus Wells Fargo 20th Annual Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Platform and pipeline overview
Focus on oncology with multiple clinical assets, including partnerships with Incyte, Lilly, and Gilead.
Platform enables development of bispecific and multispecific antibodies using established monoclonal antibody processes.
Technology leverages standard manufacturing and IgG engineering for immune engagement.
Three out of four clinical-stage assets show improved clinical success rates.
BIZENGRI approved last year; petosemtamab is a key focus for head and neck and colorectal cancers.
Petosemtamab in colorectal cancer
Petosemtamab is a bispecific antibody targeting EGFR and LGR5, with strong preclinical rationale for colorectal cancer.
Early phase 1 data in heavily pretreated patients showed no responses; current studies focus on earlier lines and genetically wild-type populations.
Safety profile is favorable, with manageable infusion-related reactions and fewer severe events than similar therapies.
Clinical update for colorectal cancer cohorts expected in the second half of the year.
Benchmarks for efficacy are based on cetuximab response rates: ~65% first-line, ~30% second-line.
Petosemtamab in head and neck cancer
Phase 1/2 data show a 63% response rate in first-line combination with pembrolizumab, nearly tripling standard rates.
One-year survival rate approaches 80%, unprecedented in this setting.
Second-line data show a 36% response rate and median survival of 12.5 months, outperforming standard therapies.
Breakthrough therapy designation granted by FDA for both first- and second-line settings.
Safety profile remains favorable, with no amplified toxicities in combination regimens.
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