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Merus (MRUS) investor relations material
Merus Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate Presentation summary31 Oct, 2025
Clinical pipeline and product highlights
Petosemtamab shows strong efficacy in 1L and 2L+ r/m HNSCC and mCRC, with phase 3 trials enrolling and robust interim data in both indications.
Bizengri® (zenocutuzumab) received accelerated FDA approval for NRG1+ pancreatic adenocarcinoma and NSCLC.
MCLA-129 demonstrates clinical activity in EGFRm and METex14 NSCLC, with ongoing trials in combination with chemotherapy.
Multiple collaboration programs from Multiclonics® platforms are advancing into the clinic.
Proprietary Biclonics® and Triclonics® platforms enable development of bispecific and trispecific antibodies and ADCs.
Petosemtamab clinical data and safety
In 1L mCRC, petosemtamab + FOLFOX/FOLFIRI showed an 80% response rate; in 2L, 62%; and in 3L+ monotherapy, 10%.
In 1L PD-L1+ r/m HNSCC with pembrolizumab, confirmed ORR was 63%, median PFS 9 months, and 12-month OS rate 79%.
In 2L+ r/m HNSCC monotherapy, ORR was 36%, with median DOR 6.2 months and OS 11.4 months.
Safety profile is favorable, with no new safety signals and manageable side effects across studies.
Phase 3 trials in r/m HNSCC expected to be substantially enrolled by year end 2025, with topline readouts in 2026.
Market opportunity and financials
Estimated 2024 worldwide sales: r/m HNSCC $4B, mCRC $7.2B, with significant unmet need and high prevalence.
Petosemtamab positioned as potential first and best-in-class bispecific in r/m HNSCC and mCRC.
Cash and cash equivalents of $817M, expected to fund operations through multiple milestones into at least 2028.
Patent estate for petosemtamab extends to at least 2045, covering composition, methods, and combinations.
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Frequently asked questions
Merus N.V. is a clinical-stage immuno-oncology company focused on developing innovative bispecific antibody therapeutics. The company specializes in creating full-length human multispecific antibodies known as Biclonics and Triclonics, which are designed to engage multiple targets, offering new approaches to treat various cancers. Merus has a broad pipeline, including candidates in different stages of clinical trials targeting solid tumors and hematologic malignancies. The company is headquartered in Utrecht, Netherlands, and its shares are listed on the Nasdaq.
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