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Mesoblast (MSB) investor relations material
Mesoblast AGM 2025 Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.AGM 2025 Presentation summary24 Nov, 2025
Mission and strategy
Aims to be the global leader in innovative, off-the-shelf allogeneic cell therapies for serious inflammatory diseases.
Focuses on commercializing RYONCIL and expanding its label indications.
Pursues profitability through strong cash flow, efficient operations, and optimal capital structure.
Transitioning to a more efficient commercial organization with new executive leadership.
Strategic partnerships and commercial collaborations are key to unlocking pipeline value.
Financial performance and position
Achieved US FDA approval for RYONCIL in December 2024 and launched in April 2025.
RYONCIL gross revenue reached $22 million in Q1 FY26, with expectations of over $30 million in Q2 FY26.
Cash balance of $145 million as of September 30, 2025.
Net operating cash usage for Q1 FY26 was $14.9 million.
Operating plan includes investment in Phase 3 programs, manufacturing, and debt management.
Commercial execution and market adoption
Over 40 centers onboarded, covering 80% of pediatric bone marrow transplants in the US.
More than 260 million US lives covered under insurance for RYONCIL.
Assigned a specific HCPCS J-Code by CMS and established a patient hub.
Initial demand for RYONCIL indicates significant unmet need in the market.
How will adult aGvHD expansion impact RYONCIL revenue?
How does opioid elimination data shape CLBP BLA?
What is the strategy for optimal capital structure?
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H1 202625 Feb, 2026
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Frequently asked questions
Mesoblast Limited is an Australian biotechnology company that develops cellular medicines based on mesenchymal lineage cells. The company’s pipeline targets inflammatory and cardiovascular diseases, with therapies in various stages of clinical development. Its operations include research, regulatory affairs, and strategic licensing. Mesoblast Limited is headquartered in Melbourne, Australia, and its shares are listed on the ASX.
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