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Metagenomi (MGX) investor relations material
Metagenomi Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary12 Aug, 2025
Executive summary
Developing curative gene editing therapeutics with lead programs in hemophilia A and secreted protein deficiencies, and collaborations in cardiometabolic and cell therapy spaces.
Advanced MGX-001 hemophilia A program toward pre-IND and ex-U.S. regulatory meetings in 2025, with IND/CTA submission planned for 2026.
Showcased early proof-of-concept data for gene editing technologies at ASGCT, including compact nucleases and CAST systems.
Collaboration revenue for Q2 2025 was $8.5M, down from $20.0M in Q2 2024, mainly due to the termination of the Moderna agreement and lower Affini-T revenue.
Net loss for Q2 2025 was $19.9M, compared to $10.7M in Q2 2024, with a six-month net loss of $44.9M versus $35.9M in the prior year period.
Financial highlights
Q2 2025 collaboration revenue: $8.5M (Q2 2024: $20.0M); six months: $12.6M (2024: $31.2M).
Q2 2025 R&D expenses: $22.5M (Q2 2024: $28.3M); six months: $47.6M (2024: $59.8M).
Q2 2025 G&A expenses: $7.0M (Q2 2024: $8.6M); six months: $13.8M (2024: $17.3M).
Net loss per share Q2 2025: $(0.54) (Q2 2024: $(0.29)); six months: $(1.21) (2024: $(1.24)).
Cash, cash equivalents, and marketable securities: $205.0M as of June 30, 2025, expected to fund operations into 2027.
Outlook and guidance
Cash and marketable securities expected to fund operations into 2027.
Plans to conduct pre-IND and ex-U.S. regulatory meetings for MGX-001 in H2 2025, with IND/CTA submissions targeted for 2026.
Cardiometabolic collaboration aims for development candidate nomination in 2025.
Anticipates increased R&D and G&A expenses as programs advance toward clinical development.
Assess MGX-001's FVIII activity data.
Explain the R&D committee's purpose.
What factors could affect forward-looking statements?
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Next Metagenomi earnings date
Q3 202512 Nov, 2025
Next Metagenomi earnings date
Q3 202512 Nov, 2025
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Frequently asked questions
Metagenomi Inc. is a biotechnology firm specializing in genetic medicines through its advanced metagenomics-derived genome editing technologies. The company leverages a proprietary toolbox that includes a variety of programmable nucleases, base editors, and RNA and DNA-mediated integration systems. These tools are designed to create precise and curative genetic therapies. Metagenomi focuses on developing these therapies to treat a range of serious diseases by harnessing naturally evolved microbial systems to enhance genome editing capabilities. The company is headquartered in Emeryville, California, and its shares are listed on the NASDAQ.
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