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MetaVia (MTVA) investor relations material
MetaVia H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Scientific rationale and program highlights
DA-1726 is a GLP-1/glucagon dual agonist with a unique 3:1 balance, aiming for superior glucose control and fat reduction in obesity patients compared to competitors with different ratios.
Phase 1 results for DA-1726 up to 32 mg showed strong glucose control and over 4% weight loss in four weeks, with a favorable safety profile.
DA-1241 is an oral GPR-119 agonist that increases natural GLP-1 production and has direct hepatic effects, showing compelling Phase 2A data in presumed NASH patients.
DA-1241 demonstrated an excellent safety profile in a 16-week Phase 2A trial, supporting further development and potential for combination therapies.
Differentiation, safety, and efficacy
DA-1726’s 3:1 GLP-1/glucagon ratio is designed to optimize both glucose control and fat loss, differentiating it from competitors like pemvidutide and retatrutide.
Early data indicate lower discontinuation rates due to adverse events compared to other dual agonists, with most GI side effects resolving after initial doses.
The ongoing 48 mg cohort in Phase 1 is testing higher efficacy and safety without titration, targeting at least 7% weight loss over eight weeks.
Advanced imaging and biomarker analysis (DEXA, FibroScan, HbA1c) are being used to assess fat loss, lean mass, and liver effects.
Strategic direction and partnerships
Plans include moving DA-1726 to Phase 2 with a focus on longer studies and broader patient populations, especially those with type 2 diabetes and NASH.
Active pursuit of partnerships or collaborations, particularly with large pharmaceutical companies seeking differentiated clinical-stage assets.
DA-1241’s development strategy centers on combination therapies, especially with FGF21 analogues and GLP-1s, to address the complex NASH landscape.
Ongoing discussions with companies closer to approval for ideal collaboration opportunities.
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