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MetaVia (MTVA) investor relations material
MetaVia H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Scientific rationale and program updates
DA-1726 is a GLP-1/glucagon dual agonist with a unique 3:1 balance, aiming for superior glucose control and fat loss in obesity and type 2 diabetes patients.
Phase I data for DA-1726 up to 32 mg showed strong glucose control and over 4% weight loss in four weeks, with a favorable safety profile.
DA-1241 is an oral GPR-119 agonist that increases natural GLP-1 production and has direct hepatic effects, with Phase IIA data showing compelling results in presumed NASH patients.
DA-1241 demonstrated an excellent safety profile in a 16-week Phase IIA study, supporting further development and potential expansion to other indications.
Differentiation and competitive landscape
DA-1726's 3:1 GLP-1/glucagon ratio is designed to optimize efficacy and tolerability, differentiating it from competitors like pemvidutide and retatrutide.
The ongoing 48 mg cohort for DA-1726 aims to achieve around 7% weight loss in eight weeks, with a focus on safety and efficacy without titration.
DEXA and FibroScan assessments are being used to evaluate fat loss, lean mass, and liver effects, targeting both obesity and NASH populations.
DA-1241 is positioned for combination strategies, especially with FGF21 analogues, to address the complex NASH landscape across fibrosis stages.
Strategic outlook and partnerships
Plans include advancing DA-1726 to Phase II, with a focus on longer studies, more patients, and key endpoints like HbA1c and liver health.
Active pursuit of partnerships and collaborations, especially with companies seeking differentiated assets in obesity and NASH.
DA-1241's strategy centers on combination therapies, with ongoing discussions for collaborations, ideally with partners close to approval.
AI-driven research with Syntekabio is accelerating indication expansion for DA-1241, aiming to identify new uses within months.
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