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The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
Mirum Pharmaceuticals
Mirum Pharmaceuticals (MIRM) investor relations material
Mirum Pharmaceuticals Corporate presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate presentation summary12 Jan, 2026
Financial performance and guidance
Net product sales grew from $75M in 2022 to $520M in 2025E, with 2026 guidance of $630–$650M.
Portfolio has multi-billion dollar peak revenue potential, with individual assets targeting $750M–$1B+ each.
Cash balance projected at $392M at end of 2025, with expectation to be cash flow positive in 2027.
Four potentially registrational topline readouts expected in the next 18 months, supporting future growth.
Commercial and pipeline portfolio
Three approved rare disease medicines and five additional indications in development.
LIVMARLI leads in ultra-rare cholestatic pruritus, with strong YoY sales growth and label expansion opportunities.
Bile acid replacement therapies (CHOLBAM, CTEXLI) address multiple high-need genetic disorders, with growing sales.
Pipeline includes volixibat for PSC/PBC, MRM-3379 for Fragile X Syndrome, and brelovitug for HDV (pending acquisition).
Clinical development and regulatory milestones
Multiple late-stage studies: VISTAS (PSC), VANTAGE (PBC), EXPAND (ultra-rare cholestasis), and AZURE (HDV) with key data readouts in 2026–2027.
LIVMARLI and volixibat have received FDA Breakthrough Therapy designations; brelovitug granted FDA Breakthrough and EU PRIME designations.
Positive interim analyses for volixibat in PSC and PBC, showing significant reductions in pruritus and bile acids.
MRM-3379 Phase 2 study in Fragile X Syndrome initiated, with topline data expected in 2027.
Volixibat PSC NDA submission timeline
Brelovitug HDV BLA submission and approval
When does Mirum expect to be cash flow positive?
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Next Mirum Pharmaceuticals earnings date
44th Annual J.P. Morgan Healthcare Conference14 Jan, 2026
Mirum Pharmaceuticals
Next Mirum Pharmaceuticals earnings date
44th Annual J.P. Morgan Healthcare Conference14 Jan, 2026
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Frequently asked questions
Mirum Pharmaceuticals Inc. is a biopharmaceutical company focused on the development and commercialization of therapies for rare liver diseases. The company targets conditions that primarily affect children and adults with limited treatment options. Mirum’s therapeutic approach addresses disorders related to bile acid metabolism, aiming to improve liver function and quality of life for patients. The company's portfolio includes both approved treatments and investigational therapies designed to manage chronic liver diseases. The company is headquartered in Foster City, California, and its shares are listed on the NASDAQ.
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