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Monopar Therapeutics (MNPR) investor relations material
Monopar Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Achieved significant progress in 2025, including multiple ALXN1840 data presentations, a key publication, and leadership team expansion in preparation for a potential ALXN1840 launch.
Strengthened balance sheet and advanced toward a planned NDA submission for ALXN1840 in Wilson disease.
Financial highlights
Cash, cash equivalents, and short-term investments totaled $140.4 million as of December 31, 2025.
Net loss for Q4 2025 was $5.2 million ($0.61/share), down from $10.9 million ($2.23/share) in Q4 2024.
Net loss for full-year 2025 was $13.7 million ($1.85/share), compared to $15.6 million ($4.11/share) in 2024.
R&D expenses for Q4 2025 were $3.9 million, down from $9.9 million in Q4 2024, mainly due to absence of one-time licensing costs.
G&A expenses for Q4 2025 rose to $2.2 million from $1.2 million in Q4 2024, driven by higher personnel and legal costs.
Outlook and guidance
Plans to submit NDA for ALXN1840 in Wilson disease in mid-2026 following recent FDA interactions.
Current funds expected to support operations through at least December 31, 2027, covering regulatory, commercial, and R&D activities.
- ALXN1840 shows long-term efficacy in Wilson disease; MNPR-101 advances in oncology trials.MNPR
Investor presentation20 Mar 2026 - Biopharma seeks to raise up to $300M for rare disease and oncology pipeline via flexible shelf offering.MNPR
Registration Filing16 Dec 2025 - Registering 705,015 shares for resale by a pharma partner after a licensing and equity deal.MNPR
Registration Filing16 Dec 2025 - Biotech registers 882,761 shares for resale after $21M private placement to fund drug development.MNPR
Registration Filing16 Dec 2025 - Key votes include director elections, auditor ratification, a reverse split, and stock plan amendment.MNPR
Proxy Filing2 Dec 2025 - Key votes include director elections, auditor ratification, reverse split, and stock plan amendment.MNPR
Proxy Filing2 Dec 2025 - Annual meeting to vote on directors, executive pay, auditor, and board governance.MNPR
Proxy Filing2 Dec 2025 - Annual meeting to elect directors, approve pay, and ratify auditor, with board support.MNPR
Proxy Filing2 Dec 2025 - $143.7M cash post-raise supports late-stage ALXN1840 and radiopharma pipeline through 2027.MNPR
Q3 202513 Nov 2025
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