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Nkarta (NKTX) investor relations material
Nkarta H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary9 Sep, 2025
Platform overview and clinical rationale
LEAP program focuses on CD19-directed CARN-K cell therapy for B-cell malignancies and autoimmune diseases, leveraging allogeneic, off-the-shelf NK cells for scalability and accessibility.
CARN-K cells offer a favorable safety profile, lack long-term persistence, and are designed for use by a broad range of clinicians.
NK-019 incorporates a chimeric antigen receptor and membrane-bound IL-15 to enhance activity and persistence.
Clinical programs and trial design
Two main INDs: NTRUST-1 (lupus nephritis, primary membranous nephropathy) and NTRUST-2 (systemic sclerosis, myositis, oncoassociated vasculitis), plus investigator-sponsored trials in systemic lupus and myasthenia gravis.
NTRUST-1 focuses on kidney outcomes using markers like serum creatinine, proteinuria, and GFR to predict long-term renal health.
Dose regimen standardized to three doses over one week for improved pharmacokinetics, B-cell depletion, and patient convenience.
Differentiation from CAR-T and translational insights
CARN-K therapies avoid severe toxicities seen in CAR-T, allow for re-dosing, and are more practical due to off-the-shelf availability.
Translational work targets robust B-cell depletion, immune reset, and disease-specific biomarkers to demonstrate efficacy.
Lymphodepletion regimen updated to fludarabine plus cyclophosphamide, aligning with transformative responses seen in CAR-T studies.
How does flu-si impact CARN-K efficacy?
What factors guide NTRUST-2 indication focus?
Explain CARN-K re-dosing strategy and benefits.
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Next Nkarta earnings date
Q3 20257 Nov, 2025
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Frequently asked questions
Nkarta Inc. is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of novel allogeneic, off-the-shelf engineered natural killer (NK) cell therapies for the treatment of cancer. The company is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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