Nykode Therapeutics
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Nykode Therapeutics (NYKD) investor relations material

Nykode Therapeutics H.C. Wainwright 28th Annual Global Investment Conference presentation summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 28th Annual Global Investment Conference presentation summary16 Sep, 2026

Investment highlights

  • Abi-suva, an off-the-shelf cancer vaccine, shows strong efficacy in HPV16+ head & neck cancer with a 38.5% ORR versus 19% for standard of care and a favorable safety profile.

  • Ongoing randomized Phase 2 Abili-T trial in 1L r/m HPV16+ head & neck cancer, with interim analysis expected in 2027.

  • Individualized neoantigen therapy (VB10.NEO) validated with positive peer Phase 3 data, strong immune responses in 100% of patients, and correlation with survival.

  • Proprietary neoantigen selection algorithm and simpler pDNA manufacturing support competitive costs and turnaround times.

  • Well-capitalized with $44.8M cash at Q2 2026 and $30.7M raised in August 2026, plus potential $35M upside from a pending tax case.

Pipeline and clinical progress

  • Abi-suva demonstrates consistent ORR improvement across head & neck and cervical cancer trials, with 39% ORR in 1L head & neck cancer.

  • VB10.NEO shows strong immunogenicity across 13 tumor types and 67 patients, with immune responses correlating with survival.

  • Tolerance platform for autoimmune diseases is in preclinical stage, with development planned for 1H 2027.

  • Abili-T Phase 2 trial protocol approved in 8 European countries, first patient dosed in May 2026, and enrollment expanding.

Clinical data and immune response

  • Abi-suva combined with checkpoint inhibitors doubles ORR compared to monotherapy in head & neck and cervical cancer.

  • HPV16-specific T-cell responses are strongly associated with lesion size reduction and clinical outcomes.

  • VB10.NEO induces long-lasting T-cell memory and de novo immune responses, with antigen-specific immunogenicity correlating with overall survival.

  • Manufacturing process for VB10.NEO is optimized for turnaround time under 6 weeks, competitive with peers.

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Frequently asked questions

Nykode Therapeutics AS is a clinical-stage biopharmaceutical company based in Oslo, Norway. The company focuses on the discovery and development of novel vaccines and immunotherapies, primarily targeting cancer and infectious diseases. Nykode leverages its proprietary modular vaccine technology, which directs antigens to antigen-presenting cells, aiming to induce strong and long-lasting immune responses. Its leading product candidates include VB10.16, a therapeutic vaccine in development for human papillomavirus (HPV)-related cancers, and VB10.NEO, a cancer neoantigen vaccine, which is in clinical trials for several types of advanced tumors. The company is headquartered in Oslo, Norway, and its shares are listed on the Oslo Stock Exchange.