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OmniAb
OmniAb (OABI) investor relations material
OmniAb Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary4 Mar, 2026
Executive summary
Ended 2025 with 107 partners and 407 active programs, including 32 in clinical development or commercialization, and expanded the partner base to include 8 of the top-10 global pharma companies.
Launched OmniUltra, a novel transgenic chicken platform, and expanded the xPloration partner access program, both aimed at expanding addressable markets and driving future growth.
Saw significant program advancement, with 25 progression events, 59 post-discovery stage programs, and strong annual growth in later-stage assets.
Entered new license agreements with Dana Farber Cancer Institute, Mabtrx Biosciences, and two global pharmaceutical companies.
Positioned for continued growth in 2026, with a robust calendar of upcoming clinical and regulatory milestones and improved business efficiency.
Financial highlights
Q4 2025 revenue was $8.4M, down from $10.8M in Q4 2024, mainly due to lower license and service revenue, partially offset by higher milestone, royalty, and xPloration revenue.
Full-year 2025 revenue was $18.7M, compared to $26.4M in 2024, reflecting declines in license, milestone, and service revenue, partially offset by $800,000 from xPloration.
Q4 2025 operating expenses decreased to $24.1M from $26.7M, with a $3.9M non-cash impairment charge; full-year operating expenses were $87.6M, down from $100.9M in 2024.
Net loss for Q4 2025 was $14.2M ($0.11/share) vs. $13.1M ($0.12/share) in Q4 2024; full-year net loss was $64.8M ($0.57/share) vs. $62M ($0.61/share) in 2024.
Ended 2025 with $54M in cash, equivalents, and short-term investments, down from $59.4M at the end of 2024.
Outlook and guidance
2026 revenue expected between $25M and $30M, with operating expenses of $80M to $85M and cash operating expenses of $50M to $55M.
Projected year-end 2026 cash balance of $30M to $35M; effective tax rate projected at 0%.
Long-term outlook anticipates a shift from milestone-driven to royalty-driven revenue, leveraging a scalable business model and over $3B in contracted milestones.
OmniUltra's role in peptide market expansion
Monetization strategy for xPloration platform
OmnidAb's speed from discovery to human trials
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Next OmniAb earnings date
Q1 20267 May, 2026
OmniAb
Next OmniAb earnings date
Q1 20267 May, 2026
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Frequently asked questions
OmniAb Inc. is a biotechnology firm specializing in the discovery and development of therapeutic antibodies. The company operates a unique discovery platform that leverages the biological intelligence of proprietary transgenic animals, including OmniRat, OmniChicken, and OmniMouse, which are engineered to produce antibodies with human sequences. This approach facilitates the development of human therapeutic candidates. The company is headquartered in Emeryville, California, and its shares are listed on the Nasdaq.
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