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Oncolytics Biotech (ONCY) investor relations material

Oncolytics Biotech Q3 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q3 2025 earnings summary11 Nov, 2025

Executive summary

  • Focused on advancing pelareorep as a platform immunotherapy for GI tumors, with ongoing and planned registration-directed clinical studies in pancreatic, anal, and colorectal cancers.

  • Announced key clinical trial updates, including a planned registration study in first-line metastatic pancreatic cancer and progress in the GOBLET study for GI cancers.

  • Formed a new GI Tumor Scientific Advisory Board to guide clinical and regulatory strategy.

  • Ended Q3 2025 with $12,352 in cash and cash equivalents, estimating funding runway into March 2026.

Financial highlights

  • Net loss for Q3 2025 was $14,400, up from $9,543 in Q3 2024; net loss for the nine months ended September 30, 2025, was $27,252, compared to $23,693 in the prior year period.

  • R&D expenses for Q3 2025 increased to $7,515 (Q3 2024: $6,794), mainly due to manufacturing, IP, and personnel costs; nine-month R&D expenses decreased to $14,407 (2024: $17,095) due to lower clinical trial and manufacturing costs.

  • G&A expenses for Q3 2025 rose to $6,325 (Q3 2024: $3,105), and for the nine months to $12,138 (2024: $9,450), driven by higher public company-related costs and professional fees.

  • Cash used in operating activities for the nine months was $18,620, with $15,401 provided by financing activities.

  • No revenue was generated; accumulated deficit reached $504,965 as of September 30, 2025.

Outlook and guidance

  • Plans to provide interim efficacy updates for GOBLET Cohort 5 and discuss accelerated approval for Cohort 4 with the FDA in early 2026.

  • Manufacturing program to focus on process validation and supply distribution for ongoing and planned studies.

  • Intends to raise additional funds through equity, strategic collaborations, or debt; filed a Form F-3 for up to US$150 million in securities.

  • Material uncertainties exist regarding the ability to continue as a going concern beyond March 2026 without additional financing.

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Frequently asked questions

Oncolytics Biotech Inc is a biotechnology company developing immuno-oncology therapies to treat various cancers. The company focuses on the development of proprietary viral-based therapies that stimulate the immune system to target and destroy cancer cells. Oncolytics Biotech conducts clinical research and collaborates with pharmaceutical and academic partners. The company is headquartered in Calgary, Canada, and its shares are listed on the NASDAQ.

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