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Investor Relations14 Oct 2025
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OnKure Therapeutics (OKUR) investor relations material
OnKure Therapeutics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary12 Aug, 2025
Executive summary
Completed merger with Reneo Pharmaceuticals, resulting in a reverse recapitalization and $65M concurrent financing; now trades on Nasdaq as OKUR.
Focused on advancing lead candidate OKI-219, a selective PI3Kα inhibitor, in Phase 1a/1b clinical trials for advanced breast cancer.
Completed enrollment in single agent and fulvestrant combination arms of PIKture-01 trial for OKI-219; data expected Q4 2025.
Initiated new expansion arms to evaluate OKI-219 in triplet combinations for HR+ and HER2+ metastatic breast cancer.
No product revenue to date; operations funded primarily through equity and convertible debt.
Financial highlights
Cash and cash equivalents totaled $83.4M as of June 30, 2025, providing runway into Q4 2026.
R&D expenses were $12.6M for Q2 2025, up from $10.8M in Q2 2024, mainly due to increased clinical and manufacturing costs.
G&A expenses were $3.7M for Q2 2025, slightly higher than $3.6M in Q2 2024, driven by personnel and professional fees.
Net loss for Q2 2025 was $15.4M ($1.14 per share), compared to $14.1M in Q2 2024.
Cash used in operating activities was $27.3M for the six months ended June 30, 2025.
Outlook and guidance
Expects R&D and G&A expenses to increase in 2025 as clinical programs advance and public company operations continue.
Data from PIKture-01 monotherapy and fulvestrant combination arms expected in Q4 2025.
Nomination of a pan-mutant selective PI3Ka inhibitor development candidate planned by end of 2025.
Cash runway projected into Q4 2026 based on current cash position.
Additional capital will be required to complete product development and commercialization; may seek equity, debt, or partnership funding.
When will the pan-mutant PI3Ka candidate be nominated?
Discuss the reasons for increased R&D expenses.
Describe the design of the pan-mutant program.
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Frequently asked questions
Reneo Pharmaceuticals Inc. is a clinical-stage pharmaceutical company focused on developing therapies for patients with rare genetic mitochondrial diseases. These diseases often involve the mitochondria's inability to efficiently produce energy for cells, impacting various bodily functions. The company is headquartered in San Diego, California, and its shares are listed on the Nasdaq.
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