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Oryzon Genomics
Oryzon Genomics (ORY) investor relations material
Oryzon Genomics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary27 Feb, 2026
Executive summary
Ended 2025 with a strong cash position of $33.3 million, following a financial turnaround earlier in the year.
Advanced two lead programs: iadademstat in oncology/hematology and vafidemstat in CNS disorders, with multiple ongoing and planned clinical trials.
Appointed Dr. Rolando Gutierrez-Esteinou as Chief Medical Officer for CNS, enhancing regulatory and clinical leadership.
Financial highlights
R&D expenses rose to $14.8 million for 2025, up from $8.7 million in 2024.
General and administrative expenses increased to $5.6 million for 2025, compared to $3.7 million in 2024.
Net loss for 2025 was $6.7 million, compared to $4.6 million in 2024.
Cash and equivalents at year-end 2025 totaled $33.3 million, up from $5.8 million at the end of 2024.
Total assets increased to $169.8 million at December 31, 2025, from $114.1 million a year earlier.
Outlook and guidance
Plans to present interim data from the ongoing AML trial at EHA in June 2026, representing about 75% of planned enrollment.
Expects to report meaningful data from the sickle cell disease RESTORE trial later in 2026.
Anticipates resubmission of the Phase III PORTICO-2 protocol for vafidemstat in BPD before year-end 2026.
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Frequently asked questions
Oryzon Genomics S.A. is a Spain-based clinical-stage biopharmaceutical company focused on the discovery and development of epigenetic therapies. The company develops small molecule inhibitors targeting specific enzymes involved in gene expression regulation, with therapeutic programs in oncology and neurodegenerative diseases. Oryzon conducts both preclinical and clinical trials and collaborates with academic and industry partners to advance its drug candidates. The company is headquartered in Barcelona, Spain, and its shares are listed on the BME.
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