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Oryzon Genomics (ORY) investor relations material
Oryzon Genomics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary30 Jul, 2025
Executive summary
Secured €52M ($61M) in financing between Dec 2024 and July 2025, including a €30M capital raise, €7M in bank loans, €13.2M EU grant, and €1.8M R&D incentives.
Terminated convertible bonds facility with Nice & Green, increasing treasury stock to 2.37M shares.
Advanced clinical pipeline: Phase III protocol for vafidemstat in BPD submitted to FDA; expansion of schizophrenia trial; new autism aggression trial in preparation.
Significant progress in iadademstat oncology trials (AML, MDS, SCLC) and expansion into non-malignant hematological indications like sickle cell disease.
Financial highlights
R&D expenses: $3.0M (Q2 2025), $5.8M (H1 2025) vs $2.3M (Q2 2024), $4.9M (H1 2024).
G&A expenses: $1.4M (Q2 2025), $2.7M (H1 2025) vs $1.2M (Q2 2024), $2.1M (H1 2024).
Net loss: $1.7M (Q2 2025), $3.4M (H1 2025) vs $1.5M (Q2 2024), $2.6M (H1 2024).
Cash and equivalents: $36.5M as of June 30, 2025.
Total assets: $162.1M (June 2025) vs $118.5M (June 2024); equity: $133.9M (June 2025) vs $92.6M (June 2024).
Outlook and guidance
FDA approval for PORTICO-2 Phase III BPD trial expected in 2H25; trial to enroll 350 patients over 18 weeks.
New Phase II trial for vafidemstat in autism aggression to launch, supported by EU grant.
Expansion of schizophrenia trial into more EU countries to accelerate recruitment.
Anticipated data updates from iadademstat oncology trials at ASH-2025 conference.
CTA approval for iadademstat in sickle cell disease expected in September 2025.
Describe PORTICO-2 BPD trial's key endpoints
Explain iadademstat's SCD mechanism of action
Detail Nice & Green facility termination impact
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Next Oryzon Genomics earnings date
Q3 202530 Oct, 2025
Next Oryzon Genomics earnings date
Q3 202530 Oct, 2025
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Frequently asked questions
Oryzon Genomics S.A. is a Spain-based clinical-stage biopharmaceutical company focused on the discovery and development of epigenetic therapies. The company develops small molecule inhibitors targeting specific enzymes involved in gene expression regulation, with therapeutic programs in oncology and neurodegenerative diseases. Oryzon conducts both preclinical and clinical trials and collaborates with academic and industry partners to advance its drug candidates. The company is headquartered in Barcelona, Spain, and its shares are listed on the BME.
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