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Oryzon Genomics (ORY) investor relations material
Oryzon Genomics Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Executive summary
Secured €52M ($61M) in financing between Dec 2024 and July 2025, including a €30M capital raise, €7M in bank loans, €13.2M EU grant, and €1.8M R&D incentives.
Terminated convertible bonds facility with Nice & Green, increasing treasury stock to 2.37M shares.
Advanced clinical pipeline: Phase III protocol for vafidemstat in BPD submitted to FDA; expansion of schizophrenia trial; new autism aggression trial in preparation.
Significant progress in iadademstat oncology trials (AML, MDS, SCLC) and expansion into non-malignant hematological indications like sickle cell disease.
Financial highlights
R&D expenses: $3.0M (Q2 2025), $5.8M (H1 2025) vs $2.3M (Q2 2024), $4.9M (H1 2024).
G&A expenses: $1.4M (Q2 2025), $2.7M (H1 2025) vs $1.2M (Q2 2024), $2.1M (H1 2024).
Net loss: $1.7M (Q2 2025), $3.4M (H1 2025) vs $1.5M (Q2 2024), $2.6M (H1 2024).
Cash and equivalents: $36.5M as of June 30, 2025.
Total assets: $162.1M (June 2025) vs $118.5M (June 2024); equity: $133.9M (June 2025) vs $92.6M (June 2024).
Outlook and guidance
FDA approval for PORTICO-2 Phase III BPD trial expected in 2H25; trial to enroll 350 patients over 18 weeks.
New Phase II trial for vafidemstat in autism aggression to launch, supported by EU grant.
Expansion of schizophrenia trial into more EU countries to accelerate recruitment.
Anticipated data updates from iadademstat oncology trials at ASH-2025 conference.
CTA approval for iadademstat in sickle cell disease expected in September 2025.
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