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Palisade Bio (PALI) investor relations material
Palisade Bio Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate Presentation summary15 Oct, 2025
Corporate highlights and mission
Focus on developing differentiated therapies for immune, inflammatory, and fibrotic diseases with significant unmet needs.
Lead asset PALI-2108 targets the multi-billion-dollar IBD market, specifically ulcerative colitis (UC) and fibrostenotic Crohn's disease (FSCD).
Raised $138 million from institutional healthcare investors, providing funding through major milestones.
PALI-2108 is the only PDE4 inhibitor prodrug in development for terminal ileum and colon, aiming for superior efficacy and tolerability.
Precision medicine CDx test in development to identify UC patient responders to PDE4 inhibitors.
Development pipeline and milestones
PALI-2108 is in Phase 1b for both UC and FSCD, with topline data reported and Phase 2 expected to start in 2026.
Key upcoming milestones include Phase 2 IND clearance and first subject dosing in 2026, with primary efficacy readouts in 2027-2028.
FSCD Phase 1b study is ongoing, with safety, PK, and PD endpoints, and first subject dosed expected in Q4 2025.
Product differentiation and mechanism
PALI-2108 is a potent, gut-restricted PDE4 inhibitor prodrug with 10-20x potency over other PDE4 inhibitors.
Localized bioactivation in the GI tract minimizes systemic exposure and adverse events, targeting only the ileum and colon.
Dual-action mechanism delivers both anti-inflammatory and anti-fibrotic effects, a novel approach for FSCD.
Machine learning-based biomarker test developed for precision UC patient selection.
FSCD market opportunity and PALI-2108 edge
UC precision medicine test strategy
Phase 2 dose adaptation risk mitigation?
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Next Palisade Bio earnings date
Q3 202511 Nov, 2025
Next Palisade Bio earnings date
Q3 202511 Nov, 2025
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Frequently asked questions
Palisade Bio Inc is a U.S.-based clinical-stage biopharmaceutical company developing therapeutics for gastrointestinal health. The company focuses on reducing post-surgical complications and improving recovery outcomes through targeted enzyme inhibitors. It collaborates with research institutions and conducts clinical trials to advance its drug candidates. The company is headquartered in Carlsbad, California, and its shares are listed on the NASDAQ.
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