)
Edge28 Nov 2025
Keeping the Streak Alive: The Story of Duolingo
How Duolingo made language learning addictive, scaled to millions of users, and built a powerful subscription business around everyday practice.
Passage Bio (PASG) investor relations material
Passage Bio Guggenheim Securities 2nd Annual Healthcare Innovation Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Guggenheim Securities 2nd Annual Healthcare Innovation Conference summary12 Nov, 2025
Program focus and differentiation
Lead clinical program targets frontotemporal dementia (FTD) with a GRN mutation, with a preclinical Huntington's disease program also in development.
Emphasis on AAV gene therapy to increase progranulin levels intracellularly, differing from competitors that block sortilin and may cap efficacy.
Study design excludes more severe patients (CDR 2), focusing on early-stage (CDR 0.5–1) to maximize potential clinical benefit.
Recruitment has been strong due to patient engagement and growing awareness, with no significant issues reported.
Additional FTDC9 patients included due to preclinical evidence and low incremental cost.
Clinical and regulatory strategy
FDA's rare disease guidance supports potential for single-arm studies in low-prevalence, fast-progressing diseases with no available treatments.
Early discussions with the FDA planned for the first half of next year to align on experimental design and registration path.
Immunosuppression protocol stabilized after initial patient, now includes short-term steroids and low-dose Eliquis for safety.
Natural history data from large, prospective studies (All FTD, GenFi) will be leveraged for comparison and biomarker validation.
Data refresh and FDA guidance expected in the first half of next year, with timing of public data release dependent on regulatory interactions.
Scientific rationale and biomarker strategy
Progranulin deficit is the clear proximal cause of neurodegeneration in FTD GRN; increasing levels intracellularly is the therapeutic goal.
Early data show CSF progranulin levels near or above the upper limit of normal with current dosing.
Plasma neurofilament light chain (NFL) used as a biomarker for neurodegeneration, with observed changes aligning with normal age-related increases.
Disease progresses rapidly (about eight years from diagnosis to death), underscoring the need for early intervention.
Study aims to slow neurodegeneration, with biomarker and MRI data supporting the approach.
What is the expected FDA feedback on study design?
Why exclude CDR 2 patients from FTD GRN study?
What is the significance of plasma neurofilament?
Partial view of Summaries dataset, powered by Quartr API
Research faster. Power your platform.
Next Passage Bio earnings date
Q4 20253 Mar, 2026
Next Passage Bio earnings date
Q4 20253 Mar, 2026
The essential earnings season companion
The #1 app for qualitative research. Live earnings calls, AI chat, transcripts, and more. All for free.
Live calls and transcripts
Listen to earnings calls, CMDs, investor conferences, and more – with a podcast-like experience.
Find what you need faster
Search for any keyword across all transcripts simultaneously.
Easily store key findings
Capturing important takeaways is as simple as it gets. Even during your lunch run or commute.
Your watchlist. Your dashboard.
Follow the companies that matter to you. Get a personalized feed with real-time updates.
Be the first to know
Set keyword alerts for any company, product, or competitor. Get notified the moment they're mentioned.
Consensus estimates
Access analyst consensus estimates, valuation multiples, and revenue segments splits.
All IR material in one place
The easiest way to stay updated during earnings season.
Global coverage
All events from public companies. Live and recorded.
Just click and listen
No webcast links. No manual registrations.
excellent app, it gives me free access to company earnings calls and annual reports. I also love the convenience of calls being available offline so I can listen in whilst doing other things and even when internet or WiFi isn't available.
)
Leroy DaleyApp Store
One of the very few apps you could call perfect. If something was to add to it, maybe the share price of the company when you search for it, but it's already excellent.
)
Eferix Drawings Google Play
This is genuinely one of the cleanest and fastest finance apps out there to track the market.
anuj283App Store
excellent app, it gives me free access to company earnings calls and annual reports. I also love the convenience of calls being available offline so I can listen in whilst doing other things and even when internet or WiFi isn't available.
Leroy DaleyApp Store
One of the very few apps you could call perfect. If something was to add to it, maybe the share price of the company when you search for it, but it's already excellent.
Eferix Drawings Google Play
This is genuinely one of the cleanest and fastest finance apps out there to track the market.
anuj283App Store
I can't remember the last time an app had such a positive impact on my investment process.
)
@ankurshah47_ x.com
Love the app! Quartr makes it really easy to keep track of earnings calls. It also includes the reports and slides to make it easier to follow along.
Amina0781App Store
Quartr is amazing, no way around it. It is the best right now for earnings calls, presentations, and the like.
@theshortbearx.com
I can't remember the last time an app had such a positive impact on my investment process.
@ankurshah47_ x.com
Love the app! Quartr makes it really easy to keep track of earnings calls. It also includes the reports and slides to make it easier to follow along.
Amina0781App Store
Quartr is amazing, no way around it. It is the best right now for earnings calls, presentations, and the like.
@theshortbearx.com
)
)
Frequently asked questions
Passage Bio Inc. is a clinical-stage genetic medicines company focused on developing transformative therapies for rare monogenic central nervous system (CNS) disorders. The company utilizes a proprietary gene therapy platform in collaboration with the University of Pennsylvania’s Gene Therapy Program to deliver adeno-associated virus (AAV)-based therapeutics directly to the CNS. Passage Bio’s pipeline includes treatments targeting conditions such as frontotemporal dementia, Krabbe disease, and other inherited neurodegenerative and neurodevelopmental disorders. The company is headquartered in Philadelphia, Pennsylvania, and its shares are listed on the NASDAQ.
Quartr provides global coverage of all investor relation material from public companies.
Mobile app: Research anytime, anywhere with the #1 app for live earnings calls, transcripts, analyst estimates, and more. All for free.
Desktop (Quartr Pro): The leading platform for qualitative research, used daily by top firms and financial institutions.
Quartr API: Build custom solutions powered by live earnings calls, live transcripts, filings and reports, slide presentations, and more.
Yes, the Quartr mobile app is free on both iOS and Android.
Yes. Quartr provides global, industry-leading live coverage of company events such as regular earnings calls, capital markets days, M&A announcements, and investor conferences. Live with zero delays. Just click and listen.
Yes, capturing important takeaways is as simple as it gets. Even during your lunch run or commute.
Yes. Follow the companies that matter to you. Get a personalized feed with real-time updates, a tailored earnings calendar, and instant alerts when earnings calls go live.
Yes. Set keyword alerts for any company, product, or competitor. Get notified the moment they're mentioned, regardless of who's talking.
Explore our global coverage