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Passage Bio
Passage Bio (PASG) investor relations material
Passage Bio Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary3 Mar, 2026
Executive summary
Enrolled first three FTD-GRN patients in Cohort 3 and treated first FTD-C9orf72 patient in Cohort 4 of the ongoing upliFT-D study.
Updated interim safety and biomarker data from upliFT-D and regulatory feedback on FTD-GRN registrational trial design expected in 1H 2026.
Advancing a preclinical Huntington's disease program with clinical candidate selection anticipated in 2H 2026.
Cash runway projected through 1Q 2027.
Financial highlights
Cash and cash equivalents were $46.3 million as of December 31, 2025, down from $76.8 million at the end of 2024.
R&D expenses for Q4 2025 were $5.4 million, and $23.3 million for the year, both lower than the prior year.
G&A expenses for Q4 2025 were $4.9 million, and $19.9 million for the year, also down year-over-year.
Net loss for Q4 2025 was $13.0 million ($4.09 per share); full-year net loss was $45.5 million ($14.35 per share), both improved from 2024.
Outlook and guidance
Updated interim safety and biomarker data from Dose 2 in upliFT-D and regulatory feedback on FTD-GRN trial design expected in 1H 2026.
Clinical candidate for Huntington's disease program to be declared in 2H 2026.
Cash expected to fund operations through 1Q 2027.
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Next Passage Bio earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
Passage Bio
Next Passage Bio earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
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Frequently asked questions
Passage Bio Inc. is a clinical-stage genetic medicines company focused on developing transformative therapies for rare monogenic central nervous system (CNS) disorders. The company utilizes a proprietary gene therapy platform in collaboration with the University of Pennsylvania’s Gene Therapy Program to deliver adeno-associated virus (AAV)-based therapeutics directly to the CNS. Passage Bio’s pipeline includes treatments targeting conditions such as frontotemporal dementia, Krabbe disease, and other inherited neurodegenerative and neurodevelopmental disorders. The company is headquartered in Philadelphia, Pennsylvania, and its shares are listed on the NASDAQ.
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