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Personalis (PSNL) investor relations material
Personalis Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary5 Aug, 2025
Executive summary
Q2 2025 revenue was $17.2M, down 24% year-over-year, mainly due to declines from Natera and pharma services, partially offset by growth in population sequencing and clinical diagnostics.
Clinical test volume grew 59% sequentially to 3,478 tests, driven by strong physician adoption of the MRD/NeXT Personal platform.
Net loss for Q2 2025 was $20.1M, compared to $12.8M last year; H1 2025 net loss was $35.8M.
Expanded Tempus partnership to include colorectal cancer and extended exclusivity through November 2029.
Presented pivotal clinical data at ASCO 2025, demonstrating NeXT Personal's predictive power and early cancer detection.
Financial highlights
Q2 2025 revenue: $17.2M (down 24% year-over-year); H1 2025 revenue: $37.8M (down 10%).
Pharma tests and services revenue declined 16% year-over-year to $11.0M, mainly due to fewer clinical trial samples from Moderna.
Population sequencing revenue rose 158% to $3.3M, driven by increased VA MVP sample processing.
Gross margin was 27.6% in Q2 2025, down from 35.6% year-over-year, impacted by unreimbursed clinical test costs and lower volume.
Cash and short-term investments totaled $173.2M at quarter end, with $13.2M used in Q2 operations and capex.
Outlook and guidance
Full-year 2025 revenue guidance lowered to $70M–$80M (from $80M–$90M), reflecting biopharma project delays and Natera relationship ending.
Q3 2025 revenue expected at $12M–$14M; pharma and other customer revenue projected at $11M–$13M.
Gross margin for 2025 projected at 22%–24%, down from 32% in 2024, due to investment in clinical test volume ahead of reimbursement.
Net loss for 2025 expected to be ~$85M, with cash usage of ~$75M, up from $47M in 2024.
Current cash and investments expected to fund operations for at least the next 12 months.
When will 2 Medicare indications be covered?
Biopharma project delays: 2026 revenue impact?
Cash position to reach cash flow breakeven?
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Next Personalis earnings date
Q3 20254 Nov, 2025
Next Personalis earnings date
Q3 20254 Nov, 2025
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Frequently asked questions
Personalis Inc is a biotechnology company that provides genomic sequencing and analytics services for cancer and other complex diseases. The company offers advanced molecular testing for research and clinical applications, including personalized cancer therapies and biomarker discovery. Personalis Inc is headquartered in Fremont, California, and its shares are listed on the NASDAQ.
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