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Pharvaris
Pharvaris (PHVS) investor relations material
Pharvaris Oppenheimer 36th Annual Healthcare Life Sciences Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Oppenheimer 36th Annual Healthcare Life Sciences Conference summary26 Feb, 2026
Company background and therapeutic focus
Celebrating its 10th anniversary, the company is advancing late-stage development for HAE, a rare genetic disorder causing painful and potentially life-threatening swelling attacks.
The main unmet need is for a highly efficacious oral therapy, as most current treatments are injectables.
Lead candidate deucrictibant is a B2 receptor antagonist, aiming for broad use in bradykinin-mediated angioedema.
Market landscape and strategy
Prophylactic treatment now dominates the HAE market, with about 63% of patients on long-term prophylaxis, representing 80% of market value.
Most patients use both on-demand and prophylactic therapies, highlighting the need for comprehensive treatment options.
The company aims to differentiate with oral options for both on-demand and prophylactic settings.
Clinical trial results and product differentiation
Phase III RAPIDe-3 trial for on-demand use met all primary and secondary endpoints, showing rapid symptom relief (1.28 hours vs. 12 hours for placebo) and early end of progression (17 minutes).
83% of attacks were resolved with a single dose, compared to 59% for a competitor, and the small softgel capsule offers ease of use.
The oral formulation is positioned as faster and more convenient than both injectables and other orals.
How will deucrictibant capture on-demand share?
Prophylaxis: How to convert ORLADEYO patients?
What drives confidence in H1 2027 cash runway?
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Next Pharvaris earnings date
The Citizens Life Sciences Conference 202610 Mar, 2026
Pharvaris
Next Pharvaris earnings date
The Citizens Life Sciences Conference 202610 Mar, 2026
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Frequently asked questions
Pharvaris N.V. is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies for rare diseases, particularly hereditary angioedema (HAE). The company specializes in creating oral bradykinin B2 receptor antagonists, offering alternatives to existing injected treatments. Its key developments include PHVS416, a soft capsule for on-demand use during acute HAE attacks, and PHVS719, an extended-release tablet aimed at preventing such attacks. Pharvaris operates primarily in the Netherlands, Switzerland, and the United States. The company is headquartered in Leiden, the Netherlands, and its shares are listed on the NASDAQ.
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