Phio Pharmaceuticals
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Phio Pharmaceuticals (PHIO) investor relations material

Phio Pharmaceuticals Second Annual Centri Capital Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Second Annual Centri Capital Conference summary14 Apr, 2026

Company overview and technology

  • Focuses on immunotherapy for skin cancers using INTASYL, a short interfering RNA technology with broad patents extending to 2044.

  • Operates as a lean virtual organization with eight employees and four subject matter experts, all with prior drug approval experience.

  • INTASYL selectively targets and silences specific genes, notably PD-1, to reactivate T cells and enhance tumor cell killing.

  • Technology is protected by 54 issued patents, covering composition, gene targets, and therapeutic indications.

Clinical development and results

  • Lead program PH-762 targets PD-1 and completed a phase I-B trial in January, showing strong efficacy and safety.

  • In the highest dose cohort, 85% response rate was observed, with 100% tumor clearance in four of six patients.

  • No dose-limiting toxicities or immune-related adverse events were reported, even at 20-fold higher doses.

  • Treatment is administered intratumorally, offering convenience and minimizing off-target effects.

Market opportunity and strategy

  • Addressable market for cutaneous squamous cell carcinoma is estimated at $20 billion, with rising incidence due to aging population.

  • No FDA-approved drugs exist for early-stage disease; current standard is surgical intervention.

  • Plans to monetize non-strategic assets through out-licensing, while focusing internal resources on two main programs.

  • Secondary program PH-894 targets BRD4 and is IND-ready, with future development pending FDA feedback on PH-762.

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