Phio Pharmaceuticals
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Phio Pharmaceuticals (PHIO) investor relations material

Phio Pharmaceuticals Q4 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q4 2025 earnings summary5 Mar, 2026

Executive summary

  • Completed treatment phase for PH-762 Phase 1b dose escalation trial with favorable safety, tolerability, and pathology data.

  • Advanced CMC and toxicology initiatives for PH-762, supporting future pivotal clinical development.

  • Presented new PH-762 data at major scientific conferences and prepared for FDA submission in Q2 2026.

Financial highlights

  • Cash and cash equivalents were $21.0 million at December 31, 2025, up from $5.4 million at December 31, 2024.

  • Net loss for 2025 was $8.7 million, or ($1.45) per share, compared to $7.2 million, or ($9.08) per share, in 2024.

  • Research and development expenses increased 27% year-over-year, driven by PH-762 program advancement and higher compensation.

  • General and administrative expenses rose 23% year-over-year due to higher professional services and stock-based compensation.

  • Multiple financings and warrant exercises in 2025 generated $23.7 million in net proceeds, extending cash runway into H1 2027.

Outlook and guidance

  • FDA submission for PH-762 next clinical study design targeted for Q2 2026.

  • Cash runway expected to extend into the first half of 2027, supporting ongoing clinical and operational activities.

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Q1 202614 May, 2026
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