Phio Pharmaceuticals (PHIO) Fireside chat summary

Introduction and agenda

• The session focused on advances in skin cancer treatment, particularly cutaneous squamous cell carcinoma, and welcomed audience questions throughout the discussion.

Background and experience of the speaker

• Dr. R. Todd Plott is a board-certified dermatologist with 30 years of experience, specializing in complex skin conditions and skin cancers.

• He serves as Chief Medical Officer for a large dermatology network, overseeing 127 offices across 18 states.

Current industry trends

• Cutaneous squamous cell carcinoma is the second most common solid tumor, with a mortality rate nearly double that of melanoma.

• Surgery remains the primary treatment, but there is significant interest in less invasive alternatives.

• Monoclonal antibodies are used for advanced stages but have limited efficacy and high rates of serious adverse events.