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Pliant Therapeutics (PLRX) investor relations material
Pliant Therapeutics Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Discontinued bexotegrast in IPF after unfavorable Phase 2b/3 results; BEACON-IPF close-out expected in Q4 2025.
Focus shifted to oncology (PLN-101095) and muscular dystrophy (PLN-101325) programs; Phase 1 oncology trial fully enrolled with data from highest dose cohorts expected by year-end 2025.
Completed voluntary prepayment of all outstanding debt in October 2025, eliminating loan obligations.
Underwent a 45% workforce reduction in Q2 2025 to align with new strategic priorities, lowering personnel-related costs.
Financial highlights
Net loss for Q3 2025 was $26.3M, down from $57.8M in Q3 2024; net loss per share improved to $0.43 from $0.95.
Research and development expenses for Q3 2025 decreased to $17.9M from $47.8M year-over-year, reflecting program discontinuation and restructuring.
General and administrative expenses fell to $10.3M from $14.3M year-over-year.
Cash, cash equivalents, and short-term investments totaled $243.3M as of September 30, 2025.
Accumulated deficit reached $835.8M as of September 30, 2025.
Outlook and guidance
Existing capital resources expected to fund operations for at least the next 12 months and beyond.
Research and development expenses projected to decrease in the near term due to program reprioritization.
Data from the highest dose cohorts of the PLN-101095 oncology trial anticipated by end of 2025.
BEACON-IPF close-out activities to be completed in Q4 2025, with results to be published.
Ongoing evaluation of business opportunities and cost savings from strategic restructuring anticipated.
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