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Plus Therapeutics (PSTV) investor relations material
Plus Therapeutics Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary30 Oct, 2025
Executive summary
Focused on developing targeted radiotherapeutics for CNS cancers, with lead candidate REYOBIQ advancing in multiple clinical trials and positive Phase 1 results in leptomeningeal metastases.
Achieved US market introduction of CNSide CSF diagnostics platform, securing first national coverage with UnitedHealthcare and CMS CLIA certification for the Houston lab.
Expanded commercial team and leadership to support CNSide scale-up and research initiatives.
Received significant grant funding, including a $17.6M CPRIT grant and a $3M DoD award, supporting clinical development and expansion into pediatric brain cancer trials.
Achieved compliance with Nasdaq equity listing requirements after a period of risk, but remains under panel monitoring and faces ongoing minimum bid price compliance challenges.
Financial highlights
Net loss of $4.4M for Q3 2025 and $16.7M for the nine months ended September 30, 2025, compared to $2.9M and $9.1M losses in the same periods of 2024.
Cash and investments rose to $16.6M at September 30, 2025, from $76K at December 31, 2024, driven by equity financings.
Grant revenue recognized was $1.4M for Q3 and $3.8M for the nine months, down from $1.5M and $4.4M in 2024.
Working capital improved to $4.0M at September 30, 2025, from a deficit of $10.3M at year-end 2024.
Q3 2025 operating loss was $4.5M, mainly due to higher compensation and professional fees.
Outlook and guidance
Expects R&D and G&A expenses to increase in the remainder of 2025 as clinical trials expand and the CNSide Test launches.
Plans to begin enrollment in the RESPECT-PBC pediatric brain cancer trial before year-end 2025.
Plans to expand commercial footprint for CNSide, clarify pivotal plan for REYOBIQ with the FDA, and strengthen financial position in capital markets in Q4 2025.
Initial CNSide commercial focus targets National Cancer Institute Designated Cancer Centers.
Ongoing need to raise additional capital to fund operations and clinical programs; inability to do so would materially impact operations.
CNSide commercial expansion beyond Texas?
REYOBIQ FDA pivotal plan clarification details?
Capital market plans to bolster finances?
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Next Plus Therapeutics earnings date
Q4 202520 Feb, 2026
Next Plus Therapeutics earnings date
Q4 202520 Feb, 2026
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Frequently asked questions
Plus Therapeutics, Inc. is a clinical-stage pharmaceutical company focused on the development of innovative therapies for rare cancers. The company leverages nanotechnology and targeted drug delivery platforms to design precision treatments, including radiotherapeutics for central nervous system cancers and other challenging oncological conditions. The company is headquartered in Austin, Texas, and its shares are listed on the NASDAQ.
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