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Prime Medicine (PRME) investor relations material
Prime Medicine KOL Event summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.KOL Event summary12 Nov, 2025
Introduction and agenda
The event focused on the liver disease franchise and strategy, with a spotlight on Wilson disease and the use of prime editing technology to develop durable cures, including market opportunity, treatment landscape, preclinical data, and clinical plans.
The agenda included presentations from management, a leading hepatologist, and the CMO, covering strategy, clinical perspectives, preclinical data, development plans, milestones, and Q&A.
KOL background and credentials
Dr. Michael Shilsky, Professor of Medicine at Yale and global expert in Wilson disease, provided clinical insights on disease presentation, diagnosis, and management.
Market insights and analysis
Wilson disease represents a significant unmet need with no curative therapies; current treatments are burdensome, have high non-adherence rates, and are limited by compliance, cost, and tolerability.
The addressable market is estimated at up to 26,000 patients in the US, Europe, and Japan, with a global commercial opportunity of $20–40 billion and 300 new cases annually.
The modular platform allows rapid expansion to additional mutations and other liver diseases, leveraging shared infrastructure and reducing costs.
Prioritize new liver indications vs. more Wilson mutations?
How does PE uniquely restore biliary copper excretion?
What criteria for patients to discontinue chelation?
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Next Prime Medicine earnings date
Jefferies London Healthcare Conference 202518 Nov, 2025
Next Prime Medicine earnings date
Jefferies London Healthcare Conference 202518 Nov, 2025
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Frequently asked questions
Prime Medicine, Inc. is a biotechnology company specializing in next-generation gene editing technologies aimed at developing curative therapies for a broad range of genetic diseases. The company utilizes its proprietary Prime Editing platform, a highly precise and versatile method of correcting disease-causing mutations in DNA, targeting nearly 90% of known genetic mutations. Prime Medicine's therapeutic focus includes areas like hematology, immunology, liver, ocular, and neuromuscular diseases. The company is headquartered in Cambridge, Massachussetts, and its shares are listed on the NASDAQ.
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