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PureTech Health (PRTC) investor relations material
PureTech Health H1 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H1 2025 earnings summary28 Aug, 2025
Executive summary
Entered 2025 with strong clinical and financial momentum, advancing late-stage programs and launching new entities including Seaport Therapeutics, Gallup Oncology, Silea (Celea) Therapeutics, and progressing key assets.
Maintained a hub-and-spoke model for early-stage asset development, efficient capital allocation, and risk mitigation.
Strong financial position with $319.6M in cash as of June 30, 2025, providing operational runway into 2028.
Management changes included interim CEO and chair appointments, with plans to add UK capital markets expertise to the board.
Significant value expected from royalties and milestones, including Cabenci and Cobenfy (KarXT), with modeled value around $300M over time.
Financial highlights
Ended H1 2025 with just under $320M in cash, cash equivalents, and short-term investments, down from $366M at FY 2024.
Total revenue for H1 2025 was $1.9M, up 542% year-over-year, driven by royalty revenue; grant revenue decreased.
Operating expenses for H1 2025 were just under $50M, down from $66.7M in H1 2024, reflecting spinouts, cost discipline, and workforce reductions.
R&D and G&A expenses expected to decrease further as Gallup and Silea (Celea) spin out.
Net loss attributable to owners was $44.6M, compared to $41.8M in H1 2024.
Outlook and guidance
Focused on securing external funding for Gallup and Silea (Celea), which will further extend cash runway and reduce direct R&D spend.
Phase III trial for Silea/Celea's lead program (deupirfenidone) in IPF expected to initiate in 2026, pending FDA alignment.
Key data readouts for Gallup Oncology's LYT200 expected in 2025 and 2026.
Vedanta’s VE303 Phase 3 topline data expected in 2026; Seaport’s Phase 2b BUOY-1 study ongoing.
What makes LYT-100 differentiated in IPF?
How does Seaport's Glyph platform work?
What is the key driver for Cobenfy sales upside?
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Next PureTech Health earnings date
H2 202529 Apr, 2026
Next PureTech Health earnings date
H2 202529 Apr, 2026
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Frequently asked questions
PureTech Health is an American clinical-stage biotherapeutics company that works with the discovery, development, and commercialization of medicines. PureTech’s pipeline includes proprietary product candidates in Phase 2 and Phase 3 clinical development that address significant unmet needs in oncology, central nervous system disorders, inflammatory disease, and gastrointestinal diseases. PureTech has a portfolio of proprietary, investigational medicines that are being developed with leading academic institutions as well as under strategic partnerships with other pharmaceutical companies.
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